The Effectiveness of N-Acetyl-L-Cysteine (L-NAC) in the Prevention of Severe Noise-Induced Hearing Loss

Details

• Personal Author:
  Davis B ; Hamernik RP ; Qiu W
• Description:
  Three groups of chinchillas were exposed to a nonGaussian continuous broadband noise at an Leq=10 5dB SPL, 8h/d for 5d. One group (N=6) received only the noise. A second group (N=6) received the noise and was additionally treated with L-NAC (325 mg/kg, i.p.). Treatment was administered twice daily for 2d prior to exposure and for 2d following the exposure. During exposure the animals received the L-NAC just prior to and immediately after each daily exposure. The third group (N=4) was exposed to the noise and received saline injections on the same schedule as the L-NAC treated animals. Auditory evoked potential recordings from the inferior colliculus were used to estimate pure tone thresholds and surface preparations of the organ of Corti quantified the sensory cell population. In all three groups PTS exceeded 50 dB at 2.0k Hz and above with severe sensory cell loss in the basal half of the cochlea. There was no statistically significant difference among the three groups in all measures of noise-induced trauma. Treatment with L-NAC did not reduce the trauma produced by a high-level, long duration, broadband noise exposure. [Description provided by NIOSH]
• Subjects:
  Animals Ear Hearing Loss Hearing Loss, Noise-Induced Laboratories Noise Occupational Health Safety Sense Organs
• Keywords:
  Acoustics Animal-studies Auditory-system Cell-biology Cell-damage Cell-function Cellular-reactions Ears Hearing-loss Laboratory-animals Noise-exposure Noise-induced-hearing-loss

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• ISSN:
  0378-5955
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  99-106
• Volume:
  239
• Issue:
  1
• NIOSHTIC Number:
  nn:20034117
• Citation:
  Hear Res 2008 May; 239(1-2):99-106
• Contact Point Address:
  Roger P. Hamernik, Auditory Research Laboratory, 107 Beaumont Hall, State University of New York, Plattsburgh, NY 12901, USA
• Email:
  roger.hamernik@plattsburgh.edu
• CAS Registry Number:
  Carboplatin (CAS RN 41575-94-4)
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Construction ; Manufacturing
• Performing Organization:
  Plattsburgh State University, New York
• Peer Reviewed:
  True
• Start Date:
  19860301
• Source Full Name:
  Hearing Research
• End Date:
  20130514
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3604ecc63f24599358d171537eec9fc8e21f77e9895f8e4b3c002edea60928564d4a97c8ff3a24719bb3ff7333bec492050598f450b61dafcac69247f64f5f22
• Download URL:
  https://stacks.cdc.gov/view/cdc/189483/cdc_189483_DS1.pdf
• File Type:
  [PDF - 189.36 KB ]