International Study of Factors Affecting Human Chromosome Translocations

Details

• Personal Author:
  Barquinero JF ; Bauchinger M ; Bennett LM ; Beskid O ; Bhatti P ; Blakey D ; Chung HW ; Darroudi F ; Edwards AA ; Ha M ; Hauptmann M ; Hayata I ; Kleinerman RA ; Kodama Y ; Lindholm C ; Littlefield LG ; Livingston G ; Nakamura N ; Nakano M ; Oestreicher U ; Roy L ; Schmid E ; Sigurdson AJ ; Sram RJ ; Stephan G ; Tawn EJ ; Tucker JD ; Voisin P ; Vorobtsova I ; Wang CY ; Whitehouse CA ; Yong LC ; Zhang W
• Description:
  Chromosome translocations in peripheral blood lymphocytes of normal, healthy humans increase with age, but the effects of gender, race, and cigarette smoking on background translocation yields have not been examined systematically. Further, the shape of the relationship between age and translocation frequency (TF) has not been definitively determined. We collected existing data from 16 laboratories in North America, Europe, and Asia on TFs measured in peripheral blood lymphocytes by fluorescence in situ hybridization whole chromosome painting among 1933 individuals. In Poisson regression models, age, ranging from newborns (cord blood) to 85 years, was strongly associated with TF and this relationship showed significant upward curvature at older ages versus a linear relationship (p < 0.001). Ever smokers had significantly higher TFs than non-smokers (rate ratio (RR) = 1.19, 95% confidence interval (CI), 1.09-1.30) and smoking modified the effect of age on TFs with a steeper age-related increase among ever smokers compared to non-smokers (p < 0.00 1). TFs did not differ by gender. Interpreting an independent effect of race was difficult owing to laboratory variation. Our study is three times larger than any pooled effort to date, confirming a suspected curvilinear relationship of TF with age. The significant effect of cigarette smoking has not been observed with previous pooled studies of TF in humans. Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Genetics Occupational Health Race Factors Risk Assessment Risk Factors Safety Smokers
• Keywords:
  Age-factors Age-groups Biological-monitoring Cell-biology Cell-growth Cell-transformation Cellular-structures Genetic-factors Racial-factors Risk-analysis Risk-factors Smoking Statistical-analysis

  More +
• ISSN:
  1383-5718
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Michigan ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  112-121
• Volume:
  652
• Issue:
  2
• NIOSHTIC Number:
  nn:20034078
• Citation:
  Mutat Res Genet Toxicol Environ Mutagen 2008 Apr; 652(2):112-121
• Contact Point Address:
  James D. Tucker, Wayne State Univ, Dept Biol Sci, 1370 Biol Sci Bldg 5047 Gullen Mall, Detroit, MI 48202
• Email:
  jtucker@biology.biosci.wayne.edu
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Transportation, Warehousing and Utilities
• Peer Reviewed:
  True
• Source Full Name:
  Mutation Research - Genetic Toxicology and Enfironmental Mutagenesis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5cc1b50ea7ba60bc215b5ab7c739172e8c4f56def996d75d5abe519001b9ab465b391cdacb57721c42faa5d36b6c576a2352709e7a8bbff1e9486e3fd5a33b30
• Download URL:
  https://stacks.cdc.gov/view/cdc/189448/cdc_189448_DS1.pdf
• File Type:
  [PDF - 504.89 KB ]