APOE 4 and Hip Fracture Risk in a Community-Based Study of Older Adults

Details

• Personal Author:
  Cauley JA ; Ganguli M ; Johnston JM
• Description:
  OBJECTIVES: To investigate whether the APOE 4 allele was associated with increased risk of hip fracture in an older community-based sample and whether such an increased risk was independent of dementia and history of falling. DESIGN: Case-control study nested within a prospective community study. SETTING: The Monongahela Valley Independent Elders Survey (MoVIES), an ongoing prospective community study of older adults in southwestern Pennsylvania. PARTICIPANTS: A total of 899 MoVIES participants (63.9% women; mean age, 76.2 years, SD = 4.9 years), who provided both information on hip fractures and blood samples for genotyping. MEASUREMENTS: Interview questions regarding hip fractures and falls, polymerase chain reaction to determine APOE genotype, and clinical assessment using a standardized protocol to determine the presence or absence of dementia. RESULTS: Twenty-five subjects reported having hip fractures in the year preceding screening interviews. Subjects with one or two APOE 4 alleles were twice as likely as subjects wiithout an APOE 4 allele to report hip fractures (age- adjusted OR = 2.1, 95% CI: 0.9-4.7). Based on multivariate analysis, subjects with a history of falling were more likely to report hip fractures (OR = 4.7, 95% CI: 2.1-10.8). After adjusting for history of falls and diagnosis of dementia, subjects with an APOE 4 allele were still twice as likely to report hip fractures (adjusted OR = 2.1,95% CI: 0.9 - 4.7). CONCLUSIONS: The APOE 4 allele appears to be a risk factor for hip fracture, independent of the effect of dementia and falling. Theoretically, this may be mediated by alterations in vitamin K metabolism. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Genetics Musculoskeletal System Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Age-factors Age-groups Bone-structure Genetic-factors Humans Risk-analysis Risk-factors Statistical-analysis
• ISSN:
  0002-8614
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSR - Division of Safety Research
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  47
• NIOSHTIC Number:
  nn:20033257
• Citation:
  J Am Geriatr Soc 1999 Nov; 47(11):1342-1345
• Contact Point Address:
  Janet Johnson, PhD, NIOSH, 1095 Willowdale Road, MS/P-1133, Morgantown, WV 26505-2888
• Email:
  paoletti@civ.bio.unipd.it
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Journal of the American Geriatrics Society
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0eb6178ca43bbd219d3b57a232d1495e92f98fc7651a7ec9acbeb7f0e19b04203f024d71e7a555b73c499c1ddd84b610f025228d77b6ff55c7e21ec1a8440a31
• Download URL:
  https://stacks.cdc.gov/view/cdc/188905/cdc_188905_DS1.pdf
• File Type:
  [PDF - 407.34 KB ]