Individualized Survival and Treatment Response Predictions in Breast Cancer Patients: Involvements of Phospho-EGFR and Phospho-Her2/Neu Proteins

Details

• Personal Author:
  Abraham J ; Castranova, Vincent ; Flynn DC ; Guo L ; Qian Y ; Shi X
• Description:
  Our robust prediction system for individual breast cancer patients combines three well-known machinelearning classifiers to provide stable and accurate clinical outcome prediction (N=269). The average performance of the selected classifiers is used as the evaluation criterion in breast cancer outcome predictions. A profile (incorporating histology, lymph node status, tumor grade, tumor stage, ER, PR, Her2/neu, patient's age and smoking status) generated over 95% accuracy in individualized disease-free survival and treatment response predictions. Furthermore, our analysis demonstrated that the measurement of phospho-EGFR and phospho-Her2/neu is more powerful in breast cancer survival prediction than that of total EGFR and total Her2/neu (p < 0.05). The incorporation of hormone receptor status, Her2/neu, patient's age and smoking status into the traditional pathologic markers creates a powerful standard to perform individualized survival and treatment outcome predictions for breast cancer patients. [Description provided by NIOSH]
• Subjects:
  Clinical Laboratory Techniques Diagnosis Neoplasms Occupational Health Safety
• Keywords:
  Breast-cancer Cancer-rates Clinical-diagnosis Clinical-techniques Clinical-tests Mathematical-models Statistical-analysis Treatment
• ISSN:
  1874-1894
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  18-31
• Volume:
  2
• NIOSHTIC Number:
  nn:20034063
• Citation:
  Open Clin Cancer J 2008 Jan; 2:18-31
• Contact Point Address:
  Yong Qian, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505
• Email:
  yaq2@cdc.gov
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  The Open Clinical Cancer Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c1d47f569ed56286f4b3b364e4291525b141d11a73e063b367cfdf43ea71b129ee0b13c9b324c36dd66197286a1adb7ba53583e17acb35e3e8454016758029b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/189439/cdc_189439_DS1.pdf
• File Type:
  [PDF - 927.42 KB ]