Individualized Survival and Treatment Response Predictions for Breast Cancers Using Phospho-EGFR, Phospho-ER, Phospho-HER2/Neu, Phospho-IGF-IR/In, Phospho-MAPK, and Phospho-p70S6K Proteins

Details

• Personal Author:
  Abraham J ; Castranova, Vincent ; Flynn DC ; Guo L ; Qian Y ; Shi X
• Description:
  The development and progression of breast cancer involves the activation of numerous protein kinases, and the change in phosphorylation is a hallmark of protein kinase activation. In this study, we identified a comprehensive profile to predict individual breast cancer patients' survival and treatment responses using the Random Committee algorithm. The profile incorporated a subset of phosphorylated signal protein expressions and several selected clinical factors of breast cancer. The parameters of our profile were identified by supervised feature selection algorithms, Gain Ratio Attribute Evaluation and Relief. The results showed that the overall accuracy of survival prediction reached 92.3% for individual breast cancer patients with the use of the expression profiles of phospho-EGFR, phospho-ER, phospho-HER2/neu, phospho-IGFIR/In, phospho-MAPK, and phospho-p70S6K plus the selected clinical factors. The results also indicated that the overall accuracy of treatment response prediction was 92.6% with the use of the level of phospho-EGFR, phospho-ER, phospho-HER2/neu, phospho-MAPK, and phospho-p70S6K plus the selected clinical information. The prediction system combines multiple signal protein activation profiles and relevant clinical information, and provides a unique guideline to aid individualized decision-making in the clinical management of breast cancer. [Description provided by NIOSH]
• Subjects:
  Clinical Laboratory Techniques Diagnosis Neoplasms Occupational Health Safety
• Keywords:
  Active Protein Kinase Author Keywords: Breast Cancer Breast-cancer Cancer-rates Clinical-diagnosis Clinical-techniques Clinical-tests Mathematical-models Prediction Statistical-analysis Survival Treatment Treatment Responses

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• ISSN:
  0393-6155
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-11
• Volume:
  22
• Issue:
  1
• NIOSHTIC Number:
  nn:20031862
• Citation:
  Int J Biol Markers 2007 Jan; 22(1):1-11
• Contact Point Address:
  Centers for Disease Control and Prevention (CDC), The Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  The International Journal of Biological Markers
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8aef81805fcab5b45d5ddca962b2a5663ad5b5a2255aaccf626ef09d4900a433f765aa92b2464e15ca1e3317bcc9542f46356721e5bf8079db4c24dd0a784b8f
• Download URL:
  https://stacks.cdc.gov/view/cdc/185986/cdc_185986_DS1.pdf
• File Type:
  [PDF - 458.87 KB ]