Carcinogenicity of Some Aromatic Amines, Organic Dyes, and Related Exposures

Details

• Personal Author:
  Baan R ; Benbrahim-Tallaa L ; Bouvard V ; Cogliano V ; El Ghissassi F ; Grosse Y ; Secretan B ; Straif K
• Corporate Authors:
  World Health Organization. International Agency for Research on Cancer. Monograph Working Group
• Description:
  In February, 2008, 17 scientists from seven countries met at the International Agency for Research on Cancer (IARC), Lyon, France, to reassess the carcinogenicity of some aromatic amines and organic dyes. Additionally, occupational exposures of hairdressers and barbers and exposure from personal use of hair colourants were reviewed. These assessments will be published as volume 99 of the IARC Monographs. Some aromatic amines have long been known to cause bladder cancer in human beings, and several others are suspected of being carcinogenic. Aromatic amines also cause bladder cancer whenever they are tested in dogs. The Working Group identified several additional aromatic amines that are carcinogenic to human beings. ortho-Toluidine is used in the production of dyes, pigments, and rubber chemicals, and as a biological stain. It is present in the urine of most people, but its origin remains unknown. In patients treated with the anaesthetic prilocaine, ortho-toluidine was detected in urine as a metabolite. Occupational exposure occurs mainly via dermal contact, and occupational cohort studies have reported greatly increased risks of bladder cancer, which could not be explained by smoking. In two of these studies, and known bladder carcinogens were present only in trace amounts and the highest risk of bladder cancer was noted in the subgroup with the longest duration of exposure. Furthermore, ortho-toluidine-haemoglobin adducts have been identified in exposed workers, as well as in patients treated with prilocaine. ortho-Toluidine also causes tumours at many sites in rodents, including bladder tumours in female rats. ortho-Toluidine was classified as carcinogenic to humans(Group 1). [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animals Benzidines Carcinogens Coloring Agents Laboratories Neoplasms Occupational Health Polyurethanes Safety Toluidines Urogenital Diseases Urogenital System

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• Keywords:
  Absorption-rates Animal-studies Bladder-cancer Dyes Genotoxic-effects Hairdressers Laboratory-animals Organic-chemicals Organic-pigments Organic-vapors Pigments Polyurethane-foams

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• ISSN:
  1470-2045
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  322-323
• Volume:
  9
• Issue:
  4
• NIOSHTIC Number:
  nn:20033977
• Citation:
  Lancet Oncol 2008 Apr; 9(4):322-323
• Federal Fiscal Year:
  2008
• Peer Reviewed:
  True
• Source Full Name:
  The Lancet Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:841dbe30816036f66751a209b98d20b4a907ea5c72114ffa7a696fba817ad6b8b4b45c5dc6e7ea57e5fcb5ce65ce0fb4522a4d2a9514d824976642cbaba01f64
• Download URL:
  https://stacks.cdc.gov/view/cdc/189371/cdc_189371_DS1.pdf
• File Type:
  [PDF - 59.11 KB ]