Laboratory-based Surveillance for Hepatitis E Virus Infection, United States, 2005–2012

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Drobeniuc, Jan ; Greene-Montfort, Tracy ; Le, Ngoc-Thao ; Mixson-Hayden, Tonya R. ; Ganova-Raeva, Lilia ; Dong, Chen ; Novak, Ryan T. ; Sharapov, Umid M. ; Tohme, Rania A. ; Teshale, Eyasu ; Kamili, Saleem ; Teo, Chong-Gee
• Description:
  To investigate characteristics of hepatitis E cases in the United States, we tested samples from persons seronegative for acute hepatitis A and B whose clinical specimens were referred to the Centers for Disease Control and Prevention during June 2005-March 2012 for hepatitis E virus (HEV) testing. We found that 26 (17%) of 154 persons tested had hepatitis E. Of these, 15 had not recently traveled abroad (nontravelers), and 11 had (travelers). Compared with travelers, nontravelers were older (median 61 vs. 32 years of age) and more likely to be anicteric (53% vs. 8%); the nontraveler group also had fewer persons of South Asian ethnicity (7% vs. 73%) and more solid-organ transplant recipients (47% vs. 0). HEV genotype 3 was characterized from 8 nontravelers and genotypes 1 or 4 from 4 travelers. Clinicians should consider HEV infection in the differential diagnosis of hepatitis, regardless of patient travel history.
• Subjects:
  Adolescent Adult Aged Antibodies, Viral CME Epidemiological Monitoring Female Genes, Viral Hepatitis E Hepatitis E Virus Humans Male Middle Aged Phylogeny Prevalence RNA, Viral Sequence Analysis, DNA Travel Young Adult

  More +
• Source:
  Emerg Infect Dis. 19(2):218-222.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  19
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:99af9118601389c3a566610e4a5c14caf2545374422e6977d37e4af69a2779e1
• Download URL:
  https://stacks.cdc.gov/view/cdc/18929/cdc_18929_DS1.pdf
• File Type:
  [PDF - 635.34 KB ]