Exposure to Dioxin and Nonneoplastic Mortality in the Expanded IARC International Cohort Study of Phenoxy Herbicide and Chlorophenol Production Workers and Sprayers

Details

• Personal Author:
  Becher H ; Benn T ; Boffetta P ; Bueno-De-Mesquita HB ; Coggon D ; Colin D ; Flesch-Janys D ; Green L ; Kauppinen T ; Kogevinas M ; Littorin N ; Lynge E ; Mathews JD ; Neuberger M ; Pearce N ; Pesatori AC ; Saracci R ; Steenland, Kyle ; Vena J
• Description:
  The authors studied noncancer mortality among phenoxyacid herbicide and chlorophenol production workers and sprayers included in an international study comprising 36 cohorts from 12 countries followed from 1939 to 1992. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin or higher chlorinated dioxins (TCDD/HCD) was discerned from job records and company questionnaires with validation by biologic and environmental measures. Standard mortality ratio analyses suggested a moderate healthy worker effect for all circulatory diseases, especially ischemic heart disease, among both those exposed and those not exposed to TCDD/HCD. In Poisson regression analyses, exposure to TCDD/HCD was not associated with increased mortality from cerebrovascular disease. However, an increased risk for circulatory disease, especially ischemic heart disease (rate ratio [RR] 1.67, 95% confidence interval [CI] 1.23-2.26) and possibly diabetes (RR 2.25, 95% CI 0.53-9.50), was present among TCDD/HCD-exposed workers. Risks tended to be higher 10 to 19 years after first exposure and for those exposed for a duration of 10 to 19 years. Mortality from suicide was comparable to that for the general population for all workers exposed to herbicides or chlorophenols and was associated with short latency and duration of exposure. More refined investigations of the ischemic heart disease and TCDD/HCD exposure association are warranted. [Description provided by NIOSH]
• Subjects:
  Biological Factors Cardiovascular Diseases Cardiovascular System Environmental Exposure Fungi Fungicide, Industrial Herbicides Hypersensitivity Insecticides Nervous System Nervous System Diseases Occupational Health Safety

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• Keywords:
  Biological-factors Cardiovascular-system-disorders Cerebrovascular-system-disorders Chemical-hypersensitivity Environmental-exposure Fungicides Hepatotoxins Pesticide-industry Pesticides Statistical-analysis
• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  116
• Issue:
  4
• NIOSHTIC Number:
  nn:20033876
• Citation:
  Environ Health Perspect 1998 Apr; 106(4)(Suppl 2):645-653
• Email:
  boffetta@iarc.fr
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6)
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Health Perspectives
• Supplement:
  2
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:78fea8631bcc6b41571426b9ae79ad60d8817a688b553a3dbb5613ba9e8ca7bec9d67417fdcbc5a454e7776f4c346afdcaca6341b5fff8109a6fc5d6b7de4ec4
• Download URL:
  https://stacks.cdc.gov/view/cdc/189289/cdc_189289_DS1.pdf
• File Type:
  [PDF - 1.80 MB ]