Study of Toxin Production by Isolates of Stachybotrys chartarum and Memnoniella echinata Isolated During a Study of Pulmonary Hemosiderosis in Infants

Details

• Personal Author:
  Dearborn D ; Etzel RA ; Hinkley S ; Hintikka EL ; Jarvis BB ; Jiang J ; Nikulin M ; Sorenson WG ; Wang SG ; Zhou YH
• Description:
  A cluster of cases of pulmonary hemosiderosis among infants was reported in Cleveland, Ohio, during 1993 and 1994. These unusual cases appeared only in infants ranging in age from 1 to 8 months and were characterized by pulmonary hemorrhage, which caused the babies to cough up blood. A case control study identified major home water damage (from plumbing leaks, roof leaks, or flooding) as a risk factor for development of pulmonary hemorrhage in these infants. Because of an interest in the possibility that trichothecene mycotoxins might be involved in this illness, a number of isolates of Stachybotrys chartarum were grown in the laboratory on rice, and extracts were prepared and analyzed both for cytotoxicity and for specific toxins. Two isolates of Memnoniella echinata, a fungus closely related to S. chartarum, were also included in these studies. S. chartarum isolates collected from the homes were shown to produce a number of highly toxic compounds, and the profiles of toxic compounds from M. echinata were similar; the most notable difference was the fact that the principal metabolites produced by M. echinata were griseofulvins. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Fungi Hazardous Substances Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Children Fungal-diseases Fungal-infections Metabolic-study Metabolism Pulmonary-disorders Pulmonary-function Pulmonary-system-disorders Toxic-materials Toxins
• ISSN:
  0099-2240
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  64
• Issue:
  10
• NIOSHTIC Number:
  nn:20033830
• Citation:
  Appl Environ Microbiol 1998 Oct; 64(10):3620-3625
• Contact Point Address:
  W. G. Sorenson, NIOSH/DRDS, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  wgs1@cdc.gov
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  True
• Source Full Name:
  Applied and Environmental Microbiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d3d5db8b60a578a38a3ca64a327553ba7e49b8b4fbf2f4269829e6a5eb575f1a903b5e727184919c424e01fbe0bcabf2c41fe3db963af7f27c4a89277d21b326
• Download URL:
  https://stacks.cdc.gov/view/cdc/189257/cdc_189257_DS1.pdf
• File Type:
  [PDF - 226.02 KB ]