Solvatochromatic Interactions Influencing Dermal Permeation of Biocides in Commercial Cutting Fluids

Details

• Personal Author:
  Baynes RE ; Vijay V
• Description:
  Linear salvation energy relationships (LSER) can be used to explain the intermolecular interactions of the solute between 2 phases and to predict the dermal permeability of solutes. The aim of this study is to determine the interactions occurring during dermal permeation of 4 phenolic biocides in 4 different formulations using a LSER approach, with a calibrated flow through diffusion cell system. Infinite doses of 4 biocides and 25 probe chemicals in water, 17% methanol and 2 commercial removal fluids namely Astrocut-C and Tapfree 2 were applied to porcine skin flow through diffusion cells. The strength coefficients for the 25 probe compounds for each system were determined from multiple linear regression analysis and plugged into the Abraham's LSER equation to predict permeability values for biocides. Biocide permeability significantly decreased in methanol, Astrocut-C and Tapfree 2 when compared to water. The strength coefficients revealed that hydrophobicity played an important role in explaining the reduced permeability in vehicles when compared to water. This finding is important for selection of biocides and cutting fluid formulations. The R2 between experimental and predicted log Kp of probe solutes for water, methanol, Astrocut-C and Tapfree 2 were 0.70, 0.78, 0.89 and 0.84 respectively. In conclusion, the LSER approach in part explained several chemical interactions resulting in reduced permeability and also predicted the dermal permeability of 4 biocides in commercial cutting fluids. Further dermal permeability of biocides will be determined in individual and combinations of different components of commercial cutting fluids to ascertain which component has prominent influence in dermal permeability. [Description provided by NIOSH]
• Subjects:
  Biochemistry Chemistry Chemistry, Analytic Dermatitis Hazardous Substances Hypersensitivity Metals Occupational Health Risk Assessment Safety Skin Skin Absorption

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• Keywords:
  Analytical-chemistry Analytical-models Biochemical-analysis Biocides Biohazards Cell-damage Chemical-hypersensitivity Contact-allergies Contact-dermatitis Cutting-oils Diffusion-analysis Mathematical-models Metalworking-fluids Physical-reactions Physiological-chemistry Quantitative-analysis Risk-analysis Skin-absorption Statistical-analysis

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  North Carolina ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  319-320
• Volume:
  102
• Issue:
  1
• NIOSHTIC Number:
  nn:20033635
• Citation:
  Toxicologist 2008 Mar; 102(1):319-320
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  False
• Start Date:
  20000801
• Source Full Name:
  The Toxicologist. Society of Toxicology 47th Annual Meeting and ToxExpo, March 16-20, 2008, Seattle, Washington
• End Date:
  20150731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f593d31f375448157785ba92e0a458b36039765cb439827acc4ae0e21965f66724c9c0957d919fbc8857d802ee3d991a25f449a8f51e4577fbcee75f1cd467de
• Download URL:
  https://stacks.cdc.gov/view/cdc/189121/cdc_189121_DS1.pdf
• File Type:
  [PDF - 7.67 MB ]