Design Strategies for Longitudinal Spirometry Studies: Duration and Frequency of Testing

Details

• Personal Author:
  Gunel E ; Petsonk, Edward L. ; Wang, Mei Lin
• Description:
  Longitudinal change in FEV1(deltaFEV1) has been useful in assessing adverse effects of exposures and/or disease processes. Differences between estimated FEV1, slope (capped beta) and "true" slope (beta), resulting from biological variation and measurement errors, expressed by the "error' term (e=l capped beta - betal), can be minimized by increasing number of subjects (N), years of follow-up (D), and/or frequency of measurements (P). To evaluate different strategies for study design, we compared the maximum error values (emax) using actual data obtained from 160 coal miners and working non-miners who had performed 11 spirometry measurements using ATS standards at 6-mo intervals over 5 years. Individual 5-yr deltaFEV1 were calculated by linear regression We determined emax by setting the probability that error is less than or equal to emax to be 95% That is P[ l capped beta - beta l < / = emax]=0.95. For the longer study durations, testing either every 6 or 12months resulted In similar errors (4 yrs - 10 vs. 16 ml/yr,5 yrs - 8vs. 11ml/yr). For 2 and 3 yr studies, errors were 4.4 and 2 times higher for 12 vs 6 monthly measurements. When designing longitudinal spirometry studies, the use of actual field test results can assist in defi8ning available options to achieve a desired value of maximum error. [Description provided by NIOSH]
• Subjects:
  Epidemiology Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Workplace
• Keywords:
  Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-system-disorders Risk-analysis Risk-factors Statistical-analysis Work-environment Worker-health Workplace-monitoring Workplace-studies

  More +
• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  159
• Issue:
  3
• NIOSHTIC Number:
  nn:20033440
• Citation:
  Am J Respir Crit Care Med 1999 Jan; 159(3)(Suppl):A319
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6806f12ebac49bcfd91cdf2e43e0b75020fc917e109f8d11d215fbcfbba620f46829c567de3f74bd11f01386b7ef89599cda46b39f8d4380ea81fef10567172a
• Download URL:
  https://stacks.cdc.gov/view/cdc/189022/cdc_189022_DS1.pdf
• File Type:
  [PDF - 1012.70 KB ]