Computer-Controlled Ozone Inhalation Exposure System

Details

• Personal Author:
  Frazer D ; McKinney W
• Description:
  Accurate systems designed to expose laboratory animals to carefully controlled concentrations of gases and aerosols are an important tool in inhalation toxicology studies. These systems are necessary for determining the dose-response relationship of toxicants under a variety of exposure conditions. The objective of this project was to develop a system, employing feedback control, to expose small laboratory animals to precise concentrations of ozone. This system needed the capability of maintaining exposures at selected levels between 0.2 to 3.0 ppm over specified periods ranging between 1 and 8 h in order to evaluate health risks associated with ozone. The overall goals of this study were (1) to develop a system capable of automatically controlling the ozone exposure levels so the steady-state error remained less than 1% and (2) to optimize the system's response time. By employing a tuned control algorithm, gas monitors, data acquisition, and a custom computer software program, these two goals were realized. [Description provided by NIOSH]
• Subjects:
  Air Movements Environmental Monitoring Laboratories Occupational Health Respiratory System Safety Toxicology
• Keywords:
  Air-flow Air-sampling-techniques Exposure-chambers Exposure-methods Inhalation-studies Laboratory-animals Laboratory-equipment
• ISSN:
  0895-8378
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  43-48
• Volume:
  20
• Issue:
  1
• NIOSHTIC Number:
  nn:20033242
• Citation:
  Inhal Toxicol 2008 Jan; 20(1):43-48
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Inhalation Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3f16e8a260c3302e292e36d5dacf62c5e7159b74717ac511ae498fa694318d54ac70f28f2f3a36429ba8d06b817a9455395ac9309a206ccb6edf312e5dffbca5
• Download URL:
  https://stacks.cdc.gov/view/cdc/188891/cdc_188891_DS1.pdf
• File Type:
  [PDF - 683.84 KB ]