Pulmonary Responses of Acute Exposure to Ultrafine Iron Particles in Healthy Adult Rats

Details

• Personal Author:
  Kennedy IM ; Pinkerton KE ; Zhong CY ; Zhou YM
• Description:
  As critical constituents of ambient particulate matter, transition metals such as iron may play an important role in health outcomes associated with air pollution. The purpose of this study was to determine the respiratory effects of inhaled ultrafine iron particles in rats. Sprague Dawley rats 10-12 weeks of age were exposed by inhalation to iron particles (57 and 90 microg/m(3), respectively) or filtered air (FA) for 6 h/day for 3 days. The median diameter of particles generated was 72 nm. Exposure to iron particles at a concentration of 90 microg/m(3) resulted in a significant decrease in total antioxidant power along with a significant induction in ferritin expression, GST activity, and IL-1beta levels in lungs compared with lungs of the FA control or of animals exposed to iron particles at 57 microg/m(3). NFkappaB-DNA binding activity was elevated 1.3-fold compared with that of control animals following exposure to 90 microg/m(3) of iron, but this change was not statistically significant. We concluded that inhalation of iron particles leads to oxidative stress associated with a proinflammatory response in a dose-dependent manner. The activation of NFkappaB may be involved in iron-induced respiratory responses, but further studies are merited. [Description provided by NIOSH]
• Subjects:
  Animals Ferrous Compounds Irritants Lung Lung Diseases Occupational Health Oxidants Particulate Matter Respiratory Function Tests Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Animal-studies Inhalation-studies Iron-compounds Iron-oxides Nanotechnology Oxidation Oxidative-metabolism Oxidative-processes Particulate-dust Particulates Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiratory-function-tests Respiratory-hypersensitivity Respiratory-irritants

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• ISSN:
  1520-4081
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  227-235
• Volume:
  18
• Issue:
  4
• NIOSHTIC Number:
  nn:20033124
• Citation:
  Environ Toxicol 2003 Aug; 18(4):227-235
• Contact Point Address:
  YM Zhou, Center for Health and the Environment, University of California, Davis, California 95616
• Email:
  kepinkerton@ucdavis.edu
• Federal Fiscal Year:
  2003
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  19900930
• Source Full Name:
  Environmental Toxicology
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3e461b1fd257ec3a0e75ff0e7d496816825fd2e747cd55bc6c3b53043d4355913bef7683e6162934586ef891c35b21aafd77f9599ab3edb906f81b79acd3509e
• Download URL:
  https://stacks.cdc.gov/view/cdc/188821/cdc_188821_DS1.pdf
• File Type:
  [PDF - 193.35 KB ]