Inflammation and Lung Cancer: Roles of Reactive Oxygen/Nitrogen Species

Details

• Personal Author:
  Azad N ; Rojanasakul Y ; Vallyathan V
• Description:
  The lung is a highly specialized organ that facilitates uptake of oxygen and release of carbon dioxide. Due to its unique structure providing enormous surface area to outside ambient air, it is vulnerable to numerous pathogens, pollutants, oxidants, gases, and toxicants that are inhaled continuously from air, which makes the lung susceptible to varying degrees of oxidative injury. To combat these unrelenting physical, chemical, and biological insults, the respiratory epithelium is covered with a thin layer of lining fluid containing several antioxidants and surfactants. Inhaled toxic agents stimulate the generation of reactive oxygen/nitrogen species (ROS/RNS), which in turn provoke inflammatory responses resulting in the release of proinflammatory cytokines and chemokines. These subsequently stimulate the influx of polymorphonuclear leukocytes (PMNs) and monocytes into the lung so as to combat the invading pathogens or toxic agents. In addition to the beneficial effects, persistent inhalation of the invading pathogens or toxic agents may result in overwhelming production of ROS/RNS, producing chronic inflammation and lung injury. During inflammation, enhanced ROS/RNS production may induce recurring DNA damage, inhibition of apoptosis, and activation of proto-oncogenes by initiating signal transduction pathways. Therefore, it is conceivable that chronic inflammation-induced production of ROS/RNS in the lung may predispose individuals to lung cancer. This review describes the complex relationship between lung inflammation and carcinogenesis, and highlights the role of ROS/RNS in cancer development. [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Lung Lung Diseases Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Cell-biology Cell-function Exposure-assessment Exposure-levels Lung-cancer Lung-cells Lung-disorders Lung-function Lung-irritants Occupational-exposure Pulmonary-system-disorders Respiratory-system-disorders

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• ISSN:
  1093-7404
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-15
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:20033081
• Citation:
  J Toxicol Environ Health B 2008 Jan; 11(1):1-15
• Contact Point Address:
  Val Vallyathan, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  vav1@cdc.gov
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing ; Mining
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part B: Critical Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:890ccbd1f3e01d036631ed610eb3318e8f91a05bb016fa5e6fa0a79d4f0a74a932fee9d6bfecfbff7e31aa72ec2f926aa45f13608fc67a996dd7589cd0822dcf
• Download URL:
  https://stacks.cdc.gov/view/cdc/188791/cdc_188791_DS1.pdf
• File Type:
  [PDF - 477.56 KB ]