Major Rat Allergens Causing Laboratory Animal Allergies

Details

• Personal Author:
  Bledsoe T ; Lewis, Dick
• Description:
  Occupational allergies can result in lost time at work and a change in position or vocation by the employee. Studies concerning the prevalence of laboratory animal allergies (LAA) have estimated the incidence of LAA among animal care workers to be eleven and thirty per cent. The rat is the most frequently reported cause of LAA (72.2%) and this study identifies the antigenic components of two major sources of rat protein: rat urine and rat epithelia. Four epithelial protein fractions and three urinary protein fractions were identified by column chromatorgaphy. These fractions were determined to have marked antigeneic activity by the radioallergosorbent (RAST) inhibition assay. The results demonstrated that the rat urinary and the rat epithelial extracts had similiar antigenic components but also each had antigenic components unique to itself. [Description provided by NIOSH]
• Subjects:
  Hypersensitivity Laboratories Occupational Health Safety
• Keywords:
  Allergens Allergic-reactions Allergies Laboratory-animals
• ISSN:
  0894-959X
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  3
• Issue:
  3
• NIOSHTIC Number:
  nn:20037454
• Citation:
  Clin Lab Sci 1990 May-Jun; 3(3):219
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  True
• Source Full Name:
  Clinical Laboratory Science
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aadfeadec4cb8382c6d7fb6873c75efac006fe43bc777a4d2fbec6cc9f27230f78fa0d466d03be03237b879a3b344f8002f6aab63735243476dc308944c7231c
• Download URL:
  https://stacks.cdc.gov/view/cdc/188549/cdc_188549_DS1.pdf
• File Type:
  [PDF - 1.22 MB ]