Effect of Cetirizine on Early- and Late-Phase Airway Responses in a Brown Norway Rat Model of Allergic Asthma

Details

• Personal Author:
  Siegel P ; Zhang X
• Description:
  Rationale: The effect of Cetirizine, a selective H1-receptor antagonist, was studied in the Brown Norway rat (BNR) model of trimellitic anhydride (TMA) early and late phase allergic asthma. Methods: Rats were sensitized by 4 hr, weekly applications of 40 mg dry TMA powder on the rats' dorsum for 4 weeks. Two weeks after the final exposure, BNR were challenged with a 10 min, 40 mg/m3 TMA aerosol inhalation exposure and enhanced pause (Penh, an index of airway resistance) was recorded continuously overnight. Cetirizine (15 or 30 mg/kg, i.p.) was given 30 min before or 1 hr after TMA challenge. Results: Both doses of Cetirizine when administered 1 hr after TMA challenge attenuated the late-phase airway response (LAR). Thirty mg/kg Cetirizine administered prior to airway challenge did not inhibit the early-phase airway response (EAR), but again the late-phase airway response was inhibited. Conclusions: The data suggest that the H-1 histamine receptor does not play a major role in the EAR, but is involved in LAR physiological response in the BNR TMA allergic asthma model. [Description provided by NIOSH]
• Subjects:
  Animals Hypersensitivity Laboratories Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Allergens Allergic-reactions Allergies Animal-studies Laboratory-animals Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  0091-6749
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  119
• Issue:
  1
• NIOSHTIC Number:
  nn:20031551
• Citation:
  J Allergy Clin Immunol 2007 Jan; 119(1)(Suppl 1):S301
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• Supplement:
  Suppl 1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b6291f34cd550a9221b19878f48b35df3e3a9a348e897e06f51ce3ccd1d1f86a14d4bc39f97de375457d21f840f90b9a3fae7c7a5392aabfdf876eb0b51c0681
• Download URL:
  https://stacks.cdc.gov/view/cdc/185801/cdc_185801_DS1.pdf
• File Type:
  [PDF - 56.36 KB ]