Antibodies to Alcalase After Industrial Exposure

Details

• Personal Author:
  Berson SA ; Saito T ; Selikoff IJ ; Yalow RS
• Description:
  Nineteen of 22 workers in a detergent factory, exposed to an enzyme additive ("Alcalase") derived from Bacillus subtilis cultures, had circulating antibodies to a component of this material; the antibodies reacted also with a component of a purified subtilisin ("Carlsberg") preparation. None of 40 unexposed subjects had this antibody. In two guinea pigs immunized with Alcalase, antibodies developed that reacted with the same component of Alcalase that reacted with the human antiserums and with similar components of two purified subtilisin preparations ("Carlsberg" and "Novo"). [Description provided by NIOSH]
• Subjects:
  Animals Antibodies Detergents Enzymes Laboratories Occupational Health Safety
• Keywords:
  Animal-studies Antibody-response Detergent-enzymes Detergent-industry Enzyme-activity Humans Laboratory-animals
• ISSN:
  0028-4793
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  284
• Issue:
  13
• NIOSHTIC Number:
  nn:20037413
• Citation:
  N Engl J Med 1971 Apr; 284(13):688-690
• Federal Fiscal Year:
  1971
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19701201
• Source Full Name:
  New England Journal of Medicine
• End Date:
  19731130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f0fb15103e33dbc06dd21c3d4073678cdea3c330067506c7b90145adf57644a1d4af00a96f03e7e4fe2d241224425d8d409839596281f6abd7999a7f14ec3620
• Download URL:
  https://stacks.cdc.gov/view/cdc/188511/cdc_188511_DS1.pdf
• File Type:
  [PDF - 503.54 KB ]