Endocrine Disruption and Reproductive Outcomes in Women

Details

• Personal Author:
  Fujimoto VY ; Guidice LC ; Janssen S
• Description:
  Infertility and associated problems of the female reproductive tract, such as endometriosis, abnormal menstrual cycles, and premature menopause, are diagnosed in women of reproductive age. For this reason, reproductive problems are usually considered to be "adult" conditions. Whereas, some female reproductive problems are the result of contaminant exposures during adulthood, there is increasing evidence that exposures early in life can result in permanent and irreversible changes to the reproductive tract, which are not manifest until decades later. A growing body of scientific evidence suggests that exposure to endocrine-disrupting chemicals (EDCs) early in life may alter development of the reproductive tract and hormonal responsiveness in adulthood. Coupled with this evidence are a number of disturbing trends in some geographic regions, including a reduction in fertility, an increase in hormone-sensitive cancers, an earlier age of puberty in girls, and a decrease in the number of boys being born. Evidence from animal studies indicates that these conditions are likely to originate during the prenatal period. Exposures to environmental contaminants early in life are of particular importance, because the reproductive system is undergoing an intricately orchestrated process of growth and differentiation. A fetus is vulnerable not only because of the rapid development and growth that are occurring, but also because it possesses immature and underdeveloped excretion pathways, low levels of chemicalbinding proteins, and an underdeveloped blood-brain barrier that is unable to protect the nervous system from toxic exposures. [Description provided by NIOSH]
• Subjects:
  Aging Agriculture Air Pollutants, Occupational Air Pollution, Indoor Chemistry Demography Environmental Monitoring Fetus Hazardous Substances Health Care Facilities Workforce And Services Hypersensitivity Insecticides Laboratories Nervous System Occupational Health Particulate Matter Pregnancy Risk Assessment Risk Factors Safety Surveys And Questionnaires Urogenital Diseases Urogenital System Women

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• Keywords:
  Age-groups Agricultural-chemicals Agricultural-industry Agricultural-processes Agricultural-products Agricultural-workers Air-contamination Airborne-particles Biological-effects Biological-function Cell-biology Cell-damage Cell-morphology Cellular-reactions Chemical-deposition Chemical-hypersensitivity Chemical-properties Children Demographic-characteristics Exposure-assessment Exposure-levels Exposure-methods Fertility Health-hazards Humans Laboratory-testing Mathematical-models Medical-monitoring Medical-surveys Neurological-reactions Neurological-system Neurotoxic-effects Neurotoxicity Neurotoxins Organic-chemicals Pathogenicity Pesticides-and-agricultural-chemicals Physiological-effects Physiological-factors Physiological-function Physiological-measurements Physiological-response Physiological-testing Pollutants Pollution Quantitative-analysis Reproductive-effects Reproductive-hazards Reproductive-system Reproductive-system-disorders Risk-analysis Risk-factors Safety-practices Statistical-analysis Surface-properties Toxic-effects

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• ISBN:
  9781588298300
• Publisher:
  Humana Press
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  California ; New Jersey ; OSHA Region 2 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  203-223
• NIOSHTIC Number:
  nn:20037293
• Citation:
  Endocrine-disrupting chemicals: from basic research to clinical practice. Gore AC, ed. Totowa, NJ: Humana Press, 2007 Jun; :203-223
• Editor(s):
  Gore AC
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Endocrine-disrupting chemicals: from basic research to clinical practice
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:86aef1f61549bdffb15f1b42e6944e93d374c06b94a5c3510dfe7d555a464a594659be52a381fd44c1dfc2751c8d69b9e2414ec56e17d42c802435045906533e
• Download URL:
  https://stacks.cdc.gov/view/cdc/188409/cdc_188409_DS1.pdf
• File Type:
  [PDF - 424.71 KB ]