Potential Pulmonary Effects of Engineered Carbon Nanotubes: In Vitro Genotoxic Effects

Details

• Personal Author:
  Castranova, Vincent ; Reynolds SH ; Sargent LM
• Description:
  The development of novel engineered nano-sized materials is a rapidly emerging technology with many applications in medicine and industry. In vitro and in vivo studies have suggested many deleterious effects of carbon nanotube exposure including granulomatous inflammation, release of cytosolic enzymes, pulmonary fibrosis, reactive oxygen damage, cellular atypia, DNA fragmentation, mutation and errors in chromosome number as well as mitotic spindle disruption. The physical properties of the carbon nanotubes make respiratory exposure to workers likely during the production or use of commercial products. Many of the investigations of the genotoxicity of carbon nanotubes have focused on reactive oxygen mediated DNA damage; however, the long thin tubular-shaped carbon nanotubes have a striking similarity to cellular microtubules. The similarity of carbon nanotubes to microtubules suggests a potential to interact with cellular biomolecules, such as the mitotic spindle, as well as the motor proteins that separate the chromosomes during cell division. Disruption of centrosomes and mitotic spindles would result in monopolar, tripolar, and quadrapolar divisions of chromosomes. The resulting aneuploidy is a key mechanism in the potential carcinogenicity of carbon nanotubes. [Description provided by NIOSH]
• Subjects:
  Carcinogens Cell Division Chromosomes DNA Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Toxicology

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• Keywords:
  Aneuploid Author Keywords: Genotoxic Carbon Nanotube Carcinogenicity Cell-damage Cell-division Cellular-reactions Chromosome-damage DNA-damage Genotoxic-effects Genotoxicity In-vitro-studies In-vivo-studies Microtubule Mitosis Mitotic Spindle Molecular-biology Molecular-structure Nanotechnology Proteins Pulmonary-disorders Respiratory-system-disorders

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• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  396-408
• Volume:
  4
• Issue:
  4
• NIOSHTIC Number:
  nn:20037238
• Citation:
  Nanotoxicology 2010 Dec; 4(4):396-408
• Contact Point Address:
  Dr Linda M. Sargent, PhD, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown WV 26505
• Email:
  LSargent@cdc.gov
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:467d2f69ca51a0dc9513bbf95a27c7127834dc589459830344ca1da89c91e7b9aa895810d6cde0065dc7cf4b7e83aa83d2ee16e2f97557be34a1643039d73d6a
• Download URL:
  https://stacks.cdc.gov/view/cdc/188361/cdc_188361_DS1.pdf
• File Type:
  [PDF - 708.12 KB ]