Urinary Levoglucosan as a Biomarker of Wood Smoke: Results of Human Exposure Studies

Details

• Personal Author:
  Bergauff MA ; Evanoski AR ; Migliaccio CT ; Noonan CW ; Palmer CP ; Simpson CD ; Ward TJ ; Bergauff MA ; Evanoski AR ; Migliaccio CT ; Noonan CW ; Palmer CP ; Simpson CD ; Ward TJ
• Description:
  Urinary levoglucosan was investigated as a potential biomarker of wood smoke exposure in two different controlled experimental settings. Nine subjects were exposed to smoke from a campfire in a controlled setting, and four were exposed to smoke from an older-model wood stove. All subjects were asked to provide urine samples before and after exposure, and to wear personal particulate matter with a diameter of < or =2.5 microm (PM(2.5)) monitors during exposure. Urinary levoglucosan measurements from both studies showed no consistent response to the smoke exposure. A third experiment was conducted to assess the contribution of dietary factors to urinary levoglucosan levels. Nine subjects were asked to consume caramel and provide urine samples before and after consumption. Urinary levoglucosan levels increased within 2 h of caramel consumption and returned to pre-exposure levels within 24 h. These studies suggest that diet is a major factor in determining urinary levoglucosan levels and that recent dietary history needs to be taken into account for future work involving levoglucosan as a biomarker of wood smoke exposure. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biomarkers Environmental Monitoring Occupational Health Particulate Matter Safety Smoke Urine
• Keywords:
  Analytical-methods Author Keywords: Wood Smoke Biochemical-analysis Control-methods Controlled-environment Exposure-assessment Exposure-levels Exposure-methods Exposure Assessment Kidney-function Levoglucosan Mathematical-models Particle-counters Particulate-sampling-methods Particulate Matter Particulates Smoke-inhalation Urinalysis Urine Urine-chemistry

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Montana ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 8 ; Pennsylvania ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  385-392
• Volume:
  20
• Issue:
  4
• NIOSHTIC Number:
  nn:20037134
• Citation:
  J Expo Sci Environ Epidemiol 2010 Jun; 20(4):385-392
• Contact Point Address:
  Dr Christopher P. Palmer, Department of Chemistry, The University of Montana, 32 Campus Drive, Missoula, MT 59801
• Email:
  christopher.palmer@umontana.edu
• Federal Fiscal Year:
  2010
• Performing Organization:
  Department of Environmental and Occupational Health Sciences, University of Washington
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20040831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4fa14d54048e5c0f8372961914a26fbd2335c5af866b020b75a82b73325643e88b038796cd0a908aee83188ae6e40720788325aa60d5ab1f30a81ac11d6fa153
• Download URL:
  https://stacks.cdc.gov/view/cdc/188283/cdc_188283_DS1.pdf
• File Type:
  [PDF - 263.57 KB ]