Pulmonary Toxicity and Extrapulmonary Tissue Distribution of Metals After Repeated Exposure to Different Welding Fumes

Details

• Personal Author:
  Antonini JM ; Chapman RS ; Ghio AJ ; Roberts, Jennifer R. ; Soukup JM ; Sriram K
• Description:
  Welders are exposed to fumes with different metal profiles. The goals of this study were to compare lung responses in rats after treatment with chemically different welding fumes and to examine the extrapulmonary fate of metals after deposition in the lungs. Rats were treated by intratracheal instillation (0.5mg/rat, once a week for 7 weeks) with gas metal arc-mild steel (GMAW-MS) or manual metal arc-hardsurfacing (MMAW-HS) welding fumes. Controls were treated with saline. At 1, 4, 35, and 105 days after the last treatment, lung injury and inflammation were measured, and elemental analysis of different organs was determined to assess metal clearance. The MMAW-HS fume was highly water-soluble and chemically more complex with higher levels of soluble Mn and Cr compared to the GMAW-MS fume. Treatments with the GMAW-MS fume had no effect on toxicity when compared with controls. The MMAW-HS fume induced significant lung damage early after treatment that remained elevated until 35 days. Metals associated with each fume sample was cleared at different rates from the lungs. Mn was cleared from the lungs at a faster rate and to a greater extent compared to the other metals over the 105-day recovery period. Mn and Cr in the MMAW-HS fume translocated from the respiratory tract and deposited in other organs. Importantly, increased deposition of Mn, but not other metals, was observed in discrete brain regions, including dopamine-rich areas (e.g., striatum and midbrain). [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animals Chromium Dust Laboratories Lung Lung Diseases Manganese Metals Occupational Health Respiratory System Respiratory Tract Diseases Safety Welding

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• Keywords:
  Animal-studies Author Keywords: Biodistribution Brain Chromium Chromium-compounds Inhalation-studies Laboratory-animals Lung-cells Lung-disorders Lung-irritants Lung Clearance Manganese Manganese-compounds Metal-compounds Metal-dusts Metal-fumes Metallic-compounds Metallic-dusts Metallic-fumes Pulmonary-disorders Pulmonary-system-disorders Pulmonary Toxicity Respiratory-system-disorders Welders Welding Fume

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• ISSN:
  0895-8378
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  10
• NIOSHTIC Number:
  nn:20037019
• Citation:
  Inhal Toxicol 2010 Aug; 22(10):805-816
• Contact Point Address:
  James M. Antonini, PhD, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
• Email:
  jga6@cdc.gov
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3) ; Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Inhalation Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5f6a671c40bdb454fb48c4a8263103e351083849204935a97f698d18f4debefb328f995d6696c1d1fca3ec3f8c4a174357dc3e5aeba21a674bfcc191ecfa6641
• Download URL:
  https://stacks.cdc.gov/view/cdc/188197/cdc_188197_DS1.pdf
• File Type:
  [PDF - 743.10 KB ]