Microprocessor of microRNAs: Regulation and Potential for Therapeutic Intervention

Details

• Personal Author:
  Beezhold KJ ; Castranova, Vincent ; Chen F
• Description:
  MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell cycle regulation, apoptosis, and transformation. Considerable progress has been made in the past few years in understanding the transcription, biogenesis and functional regulation of miRNAs. Numerous studies have implicated altered expression of miRNAs in human cancers, suggesting that aberrant expression of miRNAs is one of the hallmarks for carcinogenesis. In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs. [Description provided by NIOSH]
• Subjects:
  Carcinogens Cell Division Neoplasms Occupational Health Safety
• Keywords:
  Cancer Carcinogenesis Cell-biology Cell-division Cell-function Cell-transformation Cellular-function
• ISSN:
  1476-4598
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• NIOSHTIC Number:
  nn:20036967
• Citation:
  Mol Cancer 2010 Jun; 9:134
• Contact Point Address:
  F. Chen, Ph.D., PPRB/NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  LFD3@cdc.gov
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Manufacturing ; Mining
• Peer Reviewed:
  True
• Source Full Name:
  Molecular Cancer
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:23be01f5ec29a3622ecdf302dc944630f8b6992f3e2c353275ff7097ef9c5546ce63c1bfe47897c01effb8ba3bd8f955af3a51f2095888c99e2921077e7327a6
• Download URL:
  https://stacks.cdc.gov/view/cdc/188162/cdc_188162_DS1.pdf
• File Type:
  [PDF - 383.09 KB ]