Effects of Anticholinergic Agents on the Intestinal Absorption of 59Fe Ferrous Citrate

Details

• Personal Author:
  Fernandez O ; Mena I ; Orrego-Matte H
• Description:
  The absorption of 59Fe ferrous citrate has been studied in humans after administration of the anticholinergic agent, hexocyclium methosulfate, and in rats, after atropine. In both species, anticholinergics produced a decrease in absorption. The effect of atropine on iron absorption persisted when the radioiron was delivered intragastrically, mixed with gastric juice, but not when administered intraduodenally. Another set of experiments showed that iron absorption decreases when radioiron is intraduodenally delivered in deproteinized acid gastric juice, or in 0.10 N HCl, but not when mixed with neutralized gastric juice. It is concluded that anticholinergic drugs inhibit iron absorption by an effect on a gastric factor necessary for optimal iron absorption, and not through a decrease in acid secretion. [Description provided by NIOSH]
• Subjects:
  Acids Diet Digestive System Digestive System Diseases Environmental Monitoring Ferrous Compounds Laboratories Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Biological-effects Biological-function Cell-biology Cellular-reactions Dietary-effects Digestive-system Exposure-assessment Exposure-levels Exposure-methods Gastrointestinal-system Gastrointestinal-system-disorders Humans Iron-compounds Laboratory-animals Laboratory-testing Risk-analysis Risk-factors Statistical-analysis

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• ISSN:
  0002-9211
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  9
• NIOSHTIC Number:
  nn:20036917
• Citation:
  Am J Dig Dis 1971 Sep; 16(9):789-795
• Federal Fiscal Year:
  1971
• Performing Organization:
  Pan American Health Organization, Washington, Dist of Col
• Peer Reviewed:
  False
• Start Date:
  19701101
• Source Full Name:
  American Journal of Digestive Diseases
• End Date:
  19740731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6d888cc533d09fe2889c2f7ab2a18e309cbf9e74dc854d7bd8b71458c0aa1a2b67214e6e338a9f729000a3c043766fc0a8ca21adc51c542185fa06870daebc79
• Download URL:
  https://stacks.cdc.gov/view/cdc/188135/cdc_188135_DS1.pdf
• File Type:
  [PDF - 982.11 KB ]