Disproportionated Rosin Dehydroabietic Acid in Neoprene Surgical Gloves

Details

• Personal Author:
  Fowler JF Jr. ; Fowler LM ; Law, Brandon F. ; Siegel, Paul D.
• Description:
  BACKGROUND: Allergic contact dermatitis (ACD) is a well-recognized immune-mediated disease often associated with the use of vulcanization accelerator-containing latex and nitrile gloves. Potential contact allergens in neoprene (polychloroisoprene, polychloroprene) gloves have not been reported. OBJECTIVE: The objective was to analyze extracts of neoprene surgical and examination gloves for potential contact allergens. METHODS: Four different brands of neoprene-type gloves were purchased, and dichloromethane extracts were derivatized and assayed by gas chromatographic mass spectrometry. A latex surgical glove was used as a negative control. RESULTS: Chemical species consistent with the composition of disproportionated rosin (dehydroabietic acid [DHA], didehydroabietic acid, and other pimaric or isopimaric species) were identified in dichloromethane extracts of neoprene gloves. Levels of DHA, a type IV prohapten that can be air oxidized to an active allergen, ranged from 7 to 31 mg/g of glove. A leaching study of DHA was conducted, and small amounts of DHA leached from the glove materials into artificial sweat. DHA oxidation products were not observed in any of the gloves assayed. CONCLUSION: DHA exposure may occur from neoprene-type glove use, although a potential association with glove ACD has not been established. [Description provided by NIOSH]
• Subjects:
  Chromatography Dermatitis Hypersensitivity Immune System Occupational Health Personal Protective Equipment Safety Skin Skin Diseases Spectrum Analysis
• Keywords:
  Allergens Allergic-dermatitis Allergic-disorders Allergic-reactions Allergies Chromatographic-analysis Contact-allergies Contact-dermatitis Gloves Immune-reaction Spectrographic-analysis

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• ISSN:
  1710-3568
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  157-159
• Volume:
  21
• Issue:
  3
• NIOSHTIC Number:
  nn:20036899
• Citation:
  Dermatitis 2010 May; 21(3):157-159
• Contact Point Address:
  Centers for Disease Control (CDC), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV
• CAS Registry Number:
  Dichloromethane (CAS RN 75-09-2) ; Polychloroprene (CAS RN 9010-98-4)
• Federal Fiscal Year:
  2010
• Peer Reviewed:
  True
• Source Full Name:
  Dermatitis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cddbfbe3e4d06bf53589d74d7d24f4a222f00eb855ea677a56d4f1fe2f06dcac003c08140d48703d1fbee2ce08eb2972c6c76031a184b663900b55453350ff19
• Download URL:
  https://stacks.cdc.gov/view/cdc/188126/cdc_188126_DS1.pdf
• File Type:
  [PDF - 250.09 KB ]