Murine Models of Airway Fungal Exposure and Allergic Sensitization

Details

• Personal Author:
  Beezhold, Donald H. ; Buskirk AD ; Green, Brett J. ; Schmechel D ; Templeton SP
• Description:
  Inhalation of common indoor filamentous fungi has been associated with the induction or exacerbation of allergic respiratory disease. The understanding of fungal inhalation and allergic sensitization has significantly advanced with the use of small animal models, especially mouse models. Numerous studies have employed different animal exposure and sensitization techniques, each with inherent advantages and disadvantages that are addressed in this review. In addition, most studies involve exposure of animals to fungal spores or spore extracts while neglecting the influence of hyphal or subcellular fragment exposures. Recent literature examining the potential for hyphae and fungal fragments to induce or exacerbate allergy is discussed. Innate immune recognition of fungal elements and their contribution to lung allergic inflammation in animal models are also reviewed. Though physical properties of fungi play an important role following exposure, host immune development is also critical in airway inflammation and allergy. We discuss the importance of environmental factors that influence early immune development and subsequent susceptibility to allergy. Murine studies that examine the role of intestinal microflora and prenatal or early life environmental factors that promote allergic sensitization are also evaluated. Future studies will require animal models that accurately reflect natural fungal exposures and identify environmental factors that influence immune development and thus promote respiratory fungal allergy and disease. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Environmental Exposure Environmental Pollution Fungi Hypersensitivity Irritants Laboratories Microbiology Mycoses Occupational Health Particulate Matter Respiratory Hypersensitivity Respiratory System Safety

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• Keywords:
  Airborne-particles Allergens Allergic-disorders Allergic-reactions Analytical-processes Author Keywords: Mouse Models Environmental-exposure Environmental-hazards Environmental-pollution Exposure-levels Exposure-methods Fungal-diseases Fungal-infections Fungal Allergy Hyphae Inhalation Inhalation-studies Laboratory-animals Laboratory-testing Microorganisms Mycology Mycotoxins Respiratory-hypersensitivity Respiratory-irritants Sampling Sampling-methods Spores

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• ISSN:
  1369-3786
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  217-228
• Volume:
  48
• Issue:
  2
• NIOSHTIC Number:
  nn:20036534
• Citation:
  Med Mycol 2010 Mar; 48(2):217-228
• Contact Point Address:
  Steven P. Templeton, Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road m/s 4020, Morgantown, WV 26505
• Email:
  stempleton@cdc.gov
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Peer Reviewed:
  True
• Source Full Name:
  Medical Mycology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0bdfd98537ea81710271453f15b575a4c78efb3b1b698adf1067b5f48baa9fdb2861490e5013aa020af2bf0291211594a7027fe184412446d9fab5b634988563
• Download URL:
  https://stacks.cdc.gov/view/cdc/187917/cdc_187917_DS1.pdf
• File Type:
  [PDF - 150.52 KB ]