Circulating Adhesion Molecules After Short-Term Exposure to Particulate Matter Among Welders

Details

• Personal Author:
  Cavallari JM ; Christiani, David C. ; Eisen EA ; Fang SC ; Mittleman MA
• Description:
  BACKGROUND: Studies from several countries indicate that welders experience increased risk of mortality and morbidity from ischaemic heart disease. Although the underlying mechanisms are unclear, vascular responses to particulate matter contained in welding fumes may play a role. To investigate this, we studied the acute effects of welding fume exposure on the endothelial component of vascular function, as measured by circulating adhesion molecules involved in leukocyte adhesion (sICAM-1 and sVCAM-1) and coagulation (vWF). METHODS: A panel of 26 male welders was studied repeatedly across a 6 h work-shift on a high exposure welding day and/or a low exposure non-welding day. Personal PM(2.5) exposure was measured throughout the work-shift. Blood samples were collected in the morning (baseline) prior to the exposure period, immediately after the exposure period, and the following morning. To account for the repeated measurements, we used linear mixed models to evaluate the effects of welding (binary) and PM(2.5) (continuous) exposure on each blood marker, adjusting for baseline blood marker concentration, smoking, age and time of day. RESULTS: Welding and PM(2.5) exposure were significantly associated with a decrease in sVCAM-1 in the afternoon and the following morning and an increase in vWF in the afternoon. CONCLUSIONS: The data suggest that welding and short-term occupational exposure to PM(2.5) may acutely affect the endothelial component of vascular function. [Description provided by NIOSH]
• Subjects:
  Blood Cardiovascular Diseases Cardiovascular System Environmental Monitoring Epidemiology Hematologic Tests Men Occupational Exposure Occupational Health Particulate Matter Safety Safety Management Welding Workplace

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• Keywords:
  Analytical-methods Blood-sampling Blood-vessels Cardiac-function Cardiovascular-system Cardiovascular-system-disorders Exposure-assessment Exposure-levels Exposure-methods Heart-rate Molecular-biology Occupational-exposure Particulates Physical-stress Safety-measures Sampling-methods Statistical-analysis Task-performance Welders Work-analysis Work-operations Work-performance Workplace-monitoring Workplace-studies

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11-16
• Volume:
  67
• Issue:
  1
• NIOSHTIC Number:
  nn:20036312
• Citation:
  Occup Environ Med 2010 Jan; 67(1):11-16
• Contact Point Address:
  Shona Fang, Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, FXB 103, Boston, MA 02115
• Email:
  sfang@hsph.harvard.edu
• Federal Fiscal Year:
  2010
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8f31e4781bb9339e3361e26fffa7e24eab68ed1ff6b3c1f4c77eb28ac1b04d3b361c10db0c9196616ac964578871cfaea861c08281edf2080fa2c29e176bf1b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/187787/cdc_187787_DS1.pdf
• File Type:
  [PDF - 273.06 KB ]