Occupational Physical Activity, Energy Expenditure and 11-Year Progression of Carotid Atherosclerosis

Details

• Personal Author:
  Brand RJ ; Kaplan GA ; Kauhanen J ; Krause N ; Malla S ; Salonen JT ; Tuomainen TP
• Description:
  This study prospectively assessed the effects of occupational physical activity on atherosclerosis progression. METHODS: This population-based prospective study of ultrasonographically assessed carotid intima media thickness (IMT) used repeated measures of occupational physical activity during baseline, 4-year, and 11-year examinations of 612 Finnish men 42-60 years of age at baseline. The association between five measures of energy expenditure and the 11-year change in maximum IMT was evaluated in regression models adjusting for 21 potential confounders, including biological factors, leisure-time physical activity, smoking, socioeconomic status, psychosocial job factors, and baseline health status. RESULTS: At baseline, 31% of all the men and 51% of those with ischemic heart disease (IHD) exceeded the recommended maximum levels of relative aerobic strain. All five measures of energy expenditure were significantly associated with adjusted 11-year IMT change. Significant interactions were found between IHD and several measures of energy expenditure. Maximum relative aerobic strain resulted in a 90% increase in IMT among the men with IHD compared with a 46% increase among those without IHD. The men with preexisting carotid stenosis also had higher rates of IMT progression than the men without this condition. CONCLUSIONS: This study shows that high energy expenditures at work are associated with an accelerated progression of atherosclerosis even after control for virtually all known cardiovascular risk factors, especially among older workers and workers with preexisting IHD or carotid artery stenosis. The findings support the hemodynamic theory of atherosclerosis and have important implications for workplace surveillance and disease prevention. [Description provided by NIOSH]
• Subjects:
  Age Factors Behavior Blood Cardiovascular Diseases Cardiovascular System Mental Health Occupational Health Safety Workplace
• Keywords:
  Age-factors Blood-vessels Cardiovascular-disease Cardiovascular-system Cardiovascular-system-disorders Physical-exercise Physical-stress Psychological-responses Sociological-factors Surveillance-programs Work-analysis Work-performance Workplace-studies

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• ISSN:
  0355-3140
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  405-424
• Volume:
  33
• Issue:
  6
• NIOSHTIC Number:
  nn:20033890
• Citation:
  Scand J Work Environ Health 2007 Dec; 33(6):405-424
• Contact Point Address:
  Department of Environmental Health Sciences and UCLA Center for Occupational and Environmental Health, UCLA School of Public Health, 650 Charles Young Jr. Drive South, Los Angeles, CA 90095-1772, USA
• Federal Fiscal Year:
  2008
• Performing Organization:
  University of California, San Francisco
• Peer Reviewed:
  True
• Start Date:
  20030801
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• End Date:
  20060731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2bd1c8c357601245ef223d318cbf82b45e3e93d6ec4d4006f6436e17e38925fc35dc0fbb549b716a5ecaa216200cba744bba5f4b0f40b87adcf0db0ef86e16ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/189301/cdc_189301_DS1.pdf
• File Type:
  [PDF - 287.15 KB ]