Evaluation of Local MCP-1 and IL-12 Nanocoatings for Infection Prevention in Open Fractures

Details

• Personal Author:
  Clovis NB ; Dietz MJ ; Jiang B ; Li B ; Rao KM ; Smith ES
• Description:
  The increasing incidence of bacterial infection and the appearance of Staphylococcus aureus (S. aureus) strains that are resistant to commonly used antibiotics has made it important to develop non-antibiotic approaches for infection prevention. The aim of this study was to develop local monocyte chemoattractant protein-1 (MCP-1) and interleukin-12 p70 (IL-12 p70) therapies to prevent S. aureus infection by enhancing the recruitment and activation of macrophages, which are believed to play an important role in infection prevention as the first line of defense against invading pathogens. Nanocoating systems for MCP-1 and IL-12 p70 deliveries were prepared, and their release characteristics desirable for infection prevention in open fractures were explored. Local MCP-1 therapy reduced S. aureus infection and influenced white blood cell populations, and local IL-12 p70 treatment had a more profound effect on preventing S. aureus infection. No synergistic relationship in decreasing S. aureus infection was observed when MCP-1 and IL-12 p70 treatments were combined. This reported new approach may reduce antibiotic use and antibiotic resistance. [Description provided by NIOSH]
• Subjects:
  Bacterial Infections Communicable Diseases Occupational Health Safety
• Keywords:
  Antibiotic Resistance Author Keywords: Infection Bacterial-disease Bacterial-infections Cell-mediated Immunity Infection-control Infectious-diseases Local Drug Delivery Trauma
• ISSN:
  0736-0266
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  48-54
• Volume:
  28
• Issue:
  1
• NIOSHTIC Number:
  nn:20036259
• Citation:
  J Orthop Res 2010 Jan; 28(1):48-54
• Contact Point Address:
  Bingyun Li, Biomaterials, Bioengineering & Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia 26506
• Email:
  bli@hsc.wvu.edu
• Federal Fiscal Year:
  2010
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Orthopaedic Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ed8352881571be2c6f1970d3196a1f403f00603ab96792a5796a12ac26362edceb2fdcfa38e5e07d8ae0b635b5335ffccbb744eae34cdfaacfe532acdc8db8ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/187748/cdc_187748_DS1.pdf
• File Type:
  [PDF - 244.14 KB ]