Phylogeography of Dengue Virus Serotype 4, Brazil, 2010–2011

Nunes, Marcio Roberto Teixeira; Faria, Nuno Rodrigues; Vasconcelos, Helena Baldez; Medeiros, Daniele Barbosa de Almeida; Silva de Lima, Clayton Pereira; Carvalho, Valéria Lima; Pinto da Silva, Eliana Vieira; Cardoso, Jedson Ferreira; Sousa, Edivaldo Costa; Nunes, Keley Nascimento Barbosa; Rodrigues, Sueli Guerreiro; Abecasis, Ana Barroso; Suchard, Marc A.; Lemey, Philippe; Vasconcelos, Pedro Fernando da Costa

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Phylogeography of Dengue Virus Serotype 4, Brazil, 2010–2011

Supporting Files Public Domain

Nov 2012
By Nunes, Marcio Roberto Teixeira ; Faria, Nuno Rodrigues ; Vasconcelos, Helena Baldez ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Nunes, Marcio Roberto Teixeira ; Faria, Nuno Rodrigues ; Vasconcelos, Helena Baldez ; Medeiros, Daniele Barbosa de Almeida ; Silva de Lima, Clayton Pereira ; Carvalho, Valéria Lima ; Pinto da Silva, Eliana Vieira ; Cardoso, Jedson Ferreira ; Sousa, Edivaldo Costa ; Nunes, Keley Nascimento Barbosa ; Rodrigues, Sueli Guerreiro ; Abecasis, Ana Barroso ; Suchard, Marc A. ; Lemey, Philippe ; Vasconcelos, Pedro Fernando da Costa
Description:

Dengue virus serotype 4 (DENV-4) reemerged in Roraima State, Brazil, 28 years after it was last detected in the country in 1982. To study the origin and evolution of this reemergence, full-length sequences were obtained for 16 DENV-4 isolates from northern (Roraima, Amazonas, Pará States) and northeastern (Bahia State) Brazil during the 2010 and 2011 dengue virus seasons and for an isolate from the 1982 epidemic in Roraima. Spatiotemporal dynamics of DENV-4 introductions in Brazil were applied to envelope genes and full genomes by using Bayesian phylogeographic analyses. An introduction of genotype I into Brazil from Southeast Asia was confirmed, and full genome phylogeographic analyses revealed multiple introductions of DENV-4 genotype II in Brazil, providing evidence for >3 introductions of this genotype within the last decade: 2 from Venezuela to Roraima and 1 from Colombia to Amazonas. The phylogeographic analysis of full genome data has demonstrated the origins of DENV-4 throughout Brazil.
Subjects:

Animals Dengue Dengue Virus Genome, Viral Genotype Humans Molecular Sequence Data Phylogeny Phylogeography Research Serotyping Viral Envelope Proteins
Source:

Emerg Infect Dis. 18(11):1858-1864.
Document Type:

Journal Article
Volume:

18
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7b4cd313d9df21ed0b90989b0fc1b3fe0f7524e59a4bec3ae35de45a3817db4d
Download URL:

https://stacks.cdc.gov/view/cdc/18765/cdc_18765_DS1.pdf
File Type:

[PDF - 366.78 KB ]

File Language:

English

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