Measurement of Methamphetamine on Surfaces Using Surface Plasmon Resonance

Details

• Personal Author:
  Biagini, Raymond E. ; Cope R ; Martin A ; Quinn J ; Sammons DL ; Smith JP ; Snawder, John E. ; Striley, Cindy
• Description:
  Field methods are needed to assess the contamination of surfaces by methamphetamine from illicit drug manu facturing. This study performed a feasibility study on the use of a surface plasmon resonance (SPR) based instrument (SensiQ Discovery) in the evaluation of surface contamination by methamphetamine. The main goal was to see if the method could be sensitive enough for field measurements. A competitive immunochemical assay was developed for the instrument which was able to measure methamphetamine at 9 ng/ml with a range of 9-250 ng/ml. Methamphetamine was spiked onto ceramic tiles and the assay was able to detect methamphet amine contamination at 25 ng/100 cm(2), which is below the 50 ng/100 cm(2) standard used for surface cleanup assessment. The instrument is compact and mobile and is sensitive enough for use for measurement of meth amphetamine on surfaces, so it is a candidate for a field method for methamphetamine surface contamination. Its use for this application will require further development of the instrument to make it more convenient to use. Also further evaluation of ruggedness and use of the instrument under various environmental conditions such as temperature and humidity are needed to define conditions under which the instrument can be employed in field measurements. [Description provided by NIOSH]
• Subjects:
  Chemistry Environmental Exposure Environmental Health Environmental Monitoring Hypersensitivity Immune System Occupational Health Safety
• Keywords:
  Author Keywords: Competitive Immunoassay Chemical-cleaning Chemical-hypersensitivity Chemical-processing Environmental-exposure Environmental-factors Exposure-assessment Exposure-methods Immune-reaction Immunochemistry Methamphetamine Surface Measurement Physiological-chemistry Physiological-factors Physiological-response SPR Standards Surface-properties Surface Plasmon Resonance

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• ISSN:
  1537-6516
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  416-421
• Volume:
  19
• Issue:
  6
• NIOSHTIC Number:
  nn:20036011
• Citation:
  Toxicol Mech Methods 2009 Sep; 19(6-7):416-421
• Contact Point Address:
  Jerome P. Smith, Biomonitoring Research Team, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226
• Email:
  jps3@cdc.gov
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Services ; Public Safety
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Mechanisms and Methods
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:99fd53472dfb3c284f2893640a6303771e893ed5711ecff5098844bfe66d944274109805220874514a63c64389807afea627975a88b1efa38795992c9743e225
• Download URL:
  https://stacks.cdc.gov/view/cdc/187636/cdc_187636_DS1.pdf
• File Type:
  [PDF - 898.34 KB ]