Solid Organ Transplant–associated Lymphocytic Choriomeningitis, United States, 2011
Published Date:Aug 2012
Source:Emerg Infect Dis. 18(8):1256-1262.
Corporate Authors:LCMV Transplant Investigation Team
Lymphocytic Choriomeningitis Virus
Reverse Transcriptase Polymerase Chain Reaction
Description:Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness.
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