Occupational Exposure and Autism Spectrum Disorder

Details

• Personal Author:
  Burchfiel C ; Charles LE ; Croen LA ; Fekedulegn D ; Hertz-Picciotto I ; McCanlies EC ; Mnatsakanova A ; Sanderson, Wayne T.
• Description:
  Purpose: To evaluate associations between parental occupational exposure and autism spectrum disorder (ASD). Methods: Complete occupational, exposure, and diagnosis data were available for 228 children (93 ASD, 135 control children) and their parents enrolled in the Childhood Autism Risks from Genetics and Environment study. Three industrial hygienists (IHs) independently assessed potential occupational exposure based on the parents' listed occupation and responsibilities. Prevalence of self-reported and IHassessed exposures for mothers and fathers was calculated. Odds ratios and 95% confidence intervals were used to assess associations. Results: When the presence of exposure in at least one parent was evaluated, self-reported exposure to asphalt was positively associated with ASD (p = 0.029). Although not statistically significant, ASD was also at least twice as likely in children who had at least one parent exposed to disinfectants, solvents, phenol, styrene, lacquers and varnish. Conclusion: These results suggest that occupational exposures to some volatile chemicals may be important to consider in the etiology of ASD. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biological Factors Chemistry Environmental Monitoring Hazardous Substances Hypersensitivity Nervous System Occupational Exposure Occupational Health Paint Risk Assessment Risk Factors Safety Solvents Workplace

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• Keywords:
  Biochemical-analysis Biohazards Biological-effects Biological-factors Biological-function Biological-monitoring Chemical-hypersensitivity Chemical-indicators Chemical-properties Children Cleaning-compounds Exposure-assessment Exposure-levels Exposure-methods Neurological-system Occupational-exposure Occupational-hazards Painting Risk-analysis Risk-factors Statistical-analysis Toxic-effects Workplace-studies

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• ISSN:
  1047-2797
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  9
• NIOSHTIC Number:
  nn:20035968
• Citation:
  Ann Epidemiol 2009 Sep; 19(9):659
• Federal Fiscal Year:
  2009
• Peer Reviewed:
  False
• Source Full Name:
  Annals of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:12587d2ebfcda3b867e687145a3af96b8f6cd1f22c9e97685b6ceeeb94e15bfc59aa767b030dc711dc2f30d9c9c5daf349bd717e10889265b29cfacb846ee142
• Download URL:
  https://stacks.cdc.gov/view/cdc/187611/cdc_187611_DS1.pdf
• File Type:
  [PDF - 45.71 KB ]