Development of historical exposure estimates for an epidemiologic study of beryllium sensitization and chronic beryllium disease at a beryllium production facility.

Details

• Personal Author:
  Day, Gregory A. ; Kent MS ; Kreiss, Kathleen ; Schuler, Christine R. ; Stanton MI ; Stefaniak, Aleksandr B. ; Virji, M. Abbas
• Description:
  Background: a number of epidemiologic studies have reported elevated prevalence of beryllium sensitization and chronic beryllium disease among employees in specific work processes. However, exposure-response relationships have been inconsistent, perhaps due to exposure misclassification from a lack of accurate, precise and/or biologically relevant estimates of historical exposures. In 1999, an epidemiologic study surveyed 264 workers hired after 1/1/1994 at a beryllium production facility. Methods: personal (full-shift) beryllium exposure data from a 1999 exposure survey (n = 3,906) were used to obtain mean baseline exposure estimates (BEE) for 272 jobs in a job-exposure matrix (JEM). We used historical general-area air samples (n = 77,183) collected between 1994 and 1999 to estimate the fractional annual change in exposure for 29 different work-process areas. The data were modeled using tobit regression to account for the left censoring of the air samples (17%-98%
• Subjects:
  Biological Factors Environmental Monitoring Epidemiology Hazardous Substances Hypersensitivity Occupational Exposure Occupational Health Safety Workplace
• Keywords:
  Work-environment; Exposure-assessment; Exposure-methods; Occupational-exposure; Epidemiology; Biohazards; Biological-effects; Biological-factors; Biological-monitoring; Biological-systems; Chemical-hypersensitivity; Exposure-assessment; Exposure-levels; Exposure-methods; Statistical-analysis; Workplace-studies; Work-environment; Work-areas; Chemical-hypersensitivity
• ISSN:
  1044-3983
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  6
• NIOSHTIC Number:
  nn:20034919
• Citation:
  Epidemiology 2008 Nov; 19(6)(S):S105
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2009
• Peer Reviewed:
  False
• Source Full Name:
  Epidemiology; ISEE 20th Annual Conference, Pasadena, California, October 12-16, 2008
• Supplement:
  S
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/248024/cdc_248024_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]