Factors Affecting Initial Cholinesterase Levels from a Pilot Study of Central Wisconsin Farmers

Details

• Personal Author:
  Greenlee AR ; Stueland D
• Description:
  Measurement of cholinesterase levels can serve as an indirect estimate of exposure to organophosphate or carbamate insecticides. In addition to individual variability, there are potential predictable confounding factors that may affect the result. In a convenience sample of producers that were being evaluated for general health concerns, we performed a pilot study to evaluate parameters that might affect the group cholinesterase levels. Cholinesterase levels were found to be related to the type of grower, even though all claimed not to be exposed at the time of the tests. The plasma and red cell cholinesterase levels did not vary in the same direction between commodity groups. Plasma cholinesterase levels were higher for males than females, but red cell cholinesterase levels were not affected by gender. The plasma cholinesterase levels correlated positively with several tests of liver function whereas the red cell cholinesterase results were negatively correlated with albumin but positively correlated with age. This study underscores the fact that several parameters systematically affect cholinesterase levels. These parameters do not affect both the red cell and plasma cholinesterase similarly. These factors need to be considered when cholinesterase levels are used to compare groups of potentially exposed persons. [Description provided by NIOSH]
• Subjects:
  Agriculture Blood Chemistry Cholinesterase Inhibitors Environmental Monitoring Hazardous Substances Hematologic Tests Hypersensitivity Insecticides Occupational Health Safety Safety Management

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• Keywords:
  Agricultural-chemicals Agricultural-processes Agricultural-workers Author Keywords: Agriculture Blood-analysis Blood-cells Blood-plasma Blood-samples Blood-sampling Blood-serum Blood-tests Chemical-hypersensitivity Chemical-properties Chemical-reactions Chemical-structure Chemical-synthesis Cholinesterase-inhibitors Cholinesterase Levels Exposure-assessment Exposure-levels Exposure-limits Exposure-methods Health-hazards Health-protection Health-standards Occupational Health Safety-climate Safety-education Safety-measures Safety-monitoring Safety-personnel Safety-practices

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• ISSN:
  1074-7583
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  367-372
• Volume:
  5
• Issue:
  4
• NIOSHTIC Number:
  nn:20035956
• Citation:
  J Agric Saf Health 1999 Nov; 5(4):367-372
• Contact Point Address:
  D.Stueland, Marshfield Medical Research Foundation, Marshfield Clinic, Marshfield, Wisconsin
• Email:
  stueland@mfldclin.edu
• Federal Fiscal Year:
  2000
• NORA Priority Area:
  Disease and Injury: Traumatic Injuries
• Performing Organization:
  University of North Carolina, Chapel Hill, North Carolina
• Peer Reviewed:
  True
• Start Date:
  20000601
• Source Full Name:
  Journal of Agricultural Safety and Health
• End Date:
  20030531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5a5d6a14840547a55e746a66896d9217514fefe9901c1dc9d6e6ee63552de86b2901169d9280df2bd1691c45e5e091ead257f7f43e39e422a18b9ff504716c88
• Download URL:
  https://stacks.cdc.gov/view/cdc/187602/cdc_187602_DS1.pdf
• File Type:
  [PDF - 27.70 KB ]