Regional Induction of CYP1A1 in Rat Liver Following Treatment with Mixtures of PCB 126 and PCB 153

Details

• Personal Author:
  Andersen ME ; Billings RE ; Broccardo CJ ; Chubb LS ; Dean CE ; Hanneman WH ; Legare ME
• Description:
  Liver enzyme induction has been shown previously to be regional with clear borders between induced and uninduced regions in vivo, and cells either fully induced or not induced in vitro. The current study examined this phenomenon in vivo by evaluating enzyme induction after exposure to PCB 126 and PCB 153 in female Fisher 344 (F344) and male Sprague-Dawley (SD) rats. IHC revealed a regional induction of CYP1A1 after exposure to PCB 126, apparent in the centrilobular region at lower doses and progressing to panlobular with higher doses. PCB 153 exposure induced CYP2B1/2 in the centrilobular region, which spread to the midzonal region as the dose increased, but never became panlobular even at the highest dosage tested. In rats treated with PCB 126 in combination with high doses of PCB 153, induction of CYP1A1 occurred preferentially in the periportal region, a reversal from the pattern seen with PCB 126 alone. This CYP1A1 induction pattern reversal is a unique example of complex biological interactions between coplanar (PCB 126) and noncoplanar (PCB 153) halogenated aromatic hydrocarbons. [Description provided by NIOSH]
• Subjects:
  Agriculture Biological Products Chemistry Environment Environmental Exposure Environmental Health Environmental Monitoring Environmental Pollution Family Farmers Hazardous Substances Hypersensitivity Occupational Health Risk Assessment Risk Factors Safety Safety Management Stress, Psychological

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• Keywords:
  Agricultural-chemicals Agricultural-products Agricultural-workers Author Keywords: PCB 126 Biological-agents Biological-effects Biological-function Biological-monitoring Chemical-analysis Chemical-composition Chemical-extraction Chemical-hypersensitivity Coplanar Cytochrome P450 1A1 Cytochrome P450 2B1/2 Entertainment-industry Entertainment-workers Environmental-contamination Environmental-control Environmental-exposure Environmental-factors Environmental-hazards Environmental-health Environmental-pollution Environmental-protection Environmental-stress Exposure-assessment Exposure-levels Exposure-limits Families Health-hazards Health-protection Liver Mixtures Noncoplanar PCB 153 Risk-analysis Risk-factors Safety-climate Safety-education Safety-measures Safety-monitoring Safety-personnel

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• ISSN:
  0192-6233
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; North Carolina ; OSHA Region 4 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  467-473
• Volume:
  32
• Issue:
  4
• NIOSHTIC Number:
  nn:20035731
• Citation:
  Toxicol Pathol 2004 Jul-Aug; 32(4):467-473
• Contact Point Address:
  L. S. Chubb, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523-1680
• Email:
  Hanneman@colostate.edu
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Toxicologic Pathology
• End Date:
  20030929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b03c13c690aeae0ff523d14a85c36abec94719f5cf50faeb66c9b62b1b81973f4b519610132444d0cbea7662be23bbecd8c9d9ee08df6544c2e3cb18090f7553
• Download URL:
  https://stacks.cdc.gov/view/cdc/187490/cdc_187490_DS1.pdf
• File Type:
  [PDF - 762.36 KB ]