Evaluation of the Effects of Water Disinfection By-Products, Bromochloroacetic and Dibromoacetic Acids, on Frog Embryogenesis

Details

• Personal Author:
  Higuchi T ; Tessari J ; Veeramachaneni DN ; Weber N
• Description:
  Adverse developmental effects of two haloacetic acids, bromochloroacetic acid (BCA) and dibromoacetic acid (DBA), were determined by using the Frog Embryo Teratogenesis Assay--Xenopus (FETAX). Xenopus embryos (150-400/concentration group) were exposed to 0, 8000, 10,000, 12,000, or 14,000 ppm BCA or 0, 10,000, 12,000, 14,000, or 16,000 ppm DBA for 96 h beginning from stage 8 (mid-blastula) to stage 46 (when primary organogenesis is complete). BCA produced 29, 83, and 100% mortality at 10,000, 12,000 and 14,000 ppm, respectively. Incidence of malformations among surviving embryos at 96 h for 10,000 and 12,000 ppm BCA were 8.4 and 68%. Thus LC50 and EC50 for BCA were between 10,000 and 12,000 ppm. DBA did not produce any significant mortality or malformation at any of the concentrations tested. In summary, BCA affected development of Xenopus embryos only at high concentrations, while DBA did not affect Xenopus development at the concentrations tested. [Description provided by NIOSH]
• Subjects:
  Animals Chemistry Environment Environmental Exposure Environmental Health Environmental Monitoring Environmental Pollution Hypersensitivity Occupational Health Risk Assessment Risk Factors Safety Stress, Psychological

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• Keywords:
  Animal-studies Chemical-analysis Chemical-binding Chemical-cleaning Chemical-composition Chemical-deposition Chemical-extraction Chemical-hypersensitivity Chemical-indicators Chemical-reactions Chemical-structure Chemical-synthesis Environmental-contamination Environmental-control Environmental-exposure Environmental-factors Environmental-hazards Environmental-health Environmental-health-monitoring Environmental-pollution Environmental-protection Environmental-stress Exposure-assessment Exposure-levels Exposure-limits Exposure-methods Hazards Humans Risk-analysis Risk-factors Structural-analysis

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• ISSN:
  1528-7394
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  67
• Issue:
  12
• NIOSHTIC Number:
  nn:20035410
• Citation:
  J Toxicol Environ Health A 2004 Jun; 67(12):929-939
• Contact Point Address:
  D. N. Rao Veeramachaneni, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, CO 80523-1683, USA
• Email:
  rao@colostate.edu
• CAS Registry Number:
  Dichloroacetic acid (CAS RN 79-43-6)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• End Date:
  20030929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:52c8af259c6277529bfe781c344cc605fcd255445c174dbab686c936d4999e66862dead897ab1e8210b3f951cab4e1eac0ecfb955701ffc03e98c93327ad49da
• Download URL:
  https://stacks.cdc.gov/view/cdc/187275/cdc_187275_DS1.pdf
• File Type:
  [PDF - 5.38 MB ]