Signaling by Carcinogenic Metals and Metal-Induced Reactive Oxygen Species

Details

• Personal Author:
  Harris GK ; Shi X
• Description:
  Epidemiological data indicate that exposure to metal and metalloid species, including arsenic(III), chromium(VI), and nickel(II), increases the risk of cancer, particularly of the lung and skin. Alterations in normal signal transduction as a result of exposure to carcinogenic metals, and to metal-catalyzed reactive oxygen species (ROS) formation, appear to play an important role in the etiology of metal-induced carcinogenesis. Signaling components affected by metals include growth factor receptors, G-proteins, MAP kinases, and nuclear transcription factors. This article reviews current literature on the effects of carcinogenic metals and metal-induced ROS on cancer-related signaling pathways. In addition, the mechanisms by which those changes occur, and the role of those changes in carcinogenesis are discussed. [Description provided by NIOSH]
• Subjects:
  Carcinogens Lung Lung Diseases Metals Metals, Heavy Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Skin Skin Diseases

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• Keywords:
  Heavy-metals Lung-cancer Pulmonary-cancer Pulmonary-system-disorders Respiratory-neoplasms Respiratory-system-disorders Skin-cancer Skin-disorders
• ISSN:
  0027-5107
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  183-200
• Volume:
  533
• Issue:
  1
• NIOSHTIC Number:
  nn:20023933
• Citation:
  Mutat Res 2003 Dec; 533(1-2):183-200
• Contact Point Address:
  National Research Council Associate, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd. (M/S 2015), 26505-2888, Morgantown, WV, USA
• CAS Registry Number:
  Antimony (CAS RN 7440-36-0) ; Arsenic (CAS RN 7440-38-2) ; Beryllium (CAS RN 7440-41-7) ; Cadmium (CAS RN 7440-43-9) ; Chromium (CAS RN 7440-47-3) ; Cobalt (CAS RN 7440-48-4) ; Iron (CAS RN 7439-89-6) ; Lead (CAS RN 7439-92-1) ; Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Mutation Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4f761fbddd95f8804155e4ebd53fddac9f4a6e8ee257b45e13b6fa10e1b436d69c96b3ad5fc83726af69f55524f68370b9233a1e18dca46c481621bc41544a65
• Download URL:
  https://stacks.cdc.gov/view/cdc/195981/cdc_195981_DS1.pdf
• File Type:
  [PDF - 183.95 KB ]