Engineered Nanoparticle Respiratory Exposure and Potential Risks for Cardiovascular Toxicity: Predictive Tests and Biomarkers

Details

• Personal Author:
  Erdely A ; Simeonova PP
• Description:
  The most attractive properties of engineered nanomaterials for technological applications, including their small size, large surface area, and high reactivity, are also the main factors for their potential toxicity. Based on ambient ultrafine particle research, it is predicted that nanosized particles may have deeper pulmonary deposition, higher biological activity, and a tendency for extrapulmonary translocation compared to larger particles. In this regard, nanoparticle exposure, by direct or indirect mechanisms, may lead to unexpected distant responses, involving the immune system, cardiovascular system, liver, kidney, and brain. The systemic effects may induce or modify the progression of existing diseases such as cardiovascular disease. Current experimental toxicity evaluation of engineered nanomaterials, specifically carbon nanotubes, demonstrated that deposition of these materials in the lung leads to inflammation and fibrosis. The local toxicity is associated with cardiovascular effects related to atherosclerosis. Although translocation of carbon nanotubes into the systemic circulation is hypothetically possible, there is no current evidence to support this hypothesis. However, studies pointed out that carbon nanotubeinduced lung inflammation results in a release of inflammatory mediators and activation of blood cells which can contribute to cardiovascular adverse effects. Furthermore, complex protein and gene expression blood analysis can help in development of biomarkers for application in human screening of nanoparticle exposure. Future studies to evaluate the systemic effects of carbon nanotube exposure under workplace or environmental exposure paradigms should be conducted. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Blood Cardiovascular Diseases Cardiovascular System Dust Hazardous Substances Hematologic Tests Irritants Lung Occupational Health Particulate Matter Respiratory Function Tests Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety Workplace

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• Keywords:
  Airborne-dusts Airborne-particles Author Keywords: Atherosclerosis Biohazards Biological-effects Biological-monitoring Biological-systems Biological-transport Biomarkers Blood-analysis Blood-vessels Blood Gene Expression Breathing Cardiopulmonary-function Cardiopulmonary-system Cardiopulmonary-system-disorders Cardiovascular-disease Cardiovascular-function Cardiovascular-system Cardiovascular-system-disease Cardiovascular-system-disorders Inflammatory Cytokines Inhalation-studies Lung-function Lung-irritants Nanomaterials Nanotechnology Nanotoxicology Particle-aerodynamics Particulate-dust Particulates Predictive Tests Pulmonary-function Pulmonary-function-tests Pulmonary-system Pulmonary-system-disorders Respirable-dust Respiratory-hypersensitivity Respiratory-irritants Respiratory-system-disorders Toxic-effects Work-environment Worker-health Workplace-studies

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• ISSN:
  0895-8378
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  68-73
• Volume:
  21
• NIOSHTIC Number:
  nn:20035625
• Citation:
  Inhal Toxicol 2009 Jul; 21(S1):68-73
• Contact Point Address:
  Petia P. Simeonova, Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Dr. Morgantown, WV 26505
• Email:
  PSimeonova@cdc.gov
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Inhalation Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f32993e3488fdf1f9e36ad4be10533b9b2133d4f96c383104f378ebff47034354af31265828f126d5beeed9ad37713f7442db8242a160d7090f6e7dff12b9acb
• Download URL:
  https://stacks.cdc.gov/view/cdc/187422/cdc_187422_DS1.pdf
• File Type:
  [PDF - 829.65 KB ]