Mechanisms of Cadmium Carcinogenesis

Details

• Personal Author:
  Joseph P
• Description:
  Cadmium (Cd), a heavy metal of considerable occupational and environmental concern, has been classified as a human carcinogen by the International Agency for Research on Cancer (IARC). The carcinogenic potential of Cd as well as the mechanisms underlying carcinogenesis following exposure to Cd has been studied using in vitro cell culture and in vivo animal models. Exposure of cells to Cd results in their transformation. Administration of Cd in animals results in tumors of multiple organs/tissues. Also, a causal relationship has been noticed between exposure to Cd and the incidence of lung cancer in human. It has been demonstrated that Cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of DNA damage repair, induction of oxidative stress, and inhibition of apoptosis. The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis. [Description provided by NIOSH]
• Subjects:
  Carcinogens Environmental Exposure Environmental Monitoring Environmental Pollution Genetics Hazardous Substances Laboratories Lung Lung Diseases Neoplasms Occupational Exposure Occupational Health Oxidants Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Apoptosis Author Keywords: Cadmium Carcinogenesis Cell-damage Cell-function Cell-metabolism Cell-transformation Cellular-reactions DNA Damage Repair Environmental-exposure Environmental-hazards Exposure-assessment Exposure-levels Exposure-methods Gene Expression Genes Genetic-disorders Humans In-vitro-studies In-vivo-study Laboratory-animals Lung-cancer Lung-disease Lung-irritants Occupational-exposure Occupational-hazards Oncogenesis Oncogenic-agents Oncogenicity Oxidative-metabolism Oxidative-processes Oxidative Stress Toxic-effects

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• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  272-279
• Volume:
  238
• Issue:
  3
• NIOSHTIC Number:
  nn:20035623
• Citation:
  Toxicol Appl Pharmacol 2009 Aug; 238(3):272-279
• Contact Point Address:
  Pius Joseph, Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, MS 3014, Morgantown, WV 26505
• Email:
  pjoseph1@cdc.gov
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9)
• Federal Fiscal Year:
  2009
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b88ecdb0b74af0ac7ea0c534758a9a40af1ebf2ff602761a2875ff8e4a022d4580eeaf65dc52d3f23c1e1e790a93062d45f0f4c8cecf954403d532288e85526d
• Download URL:
  https://stacks.cdc.gov/view/cdc/187420/cdc_187420_DS1.pdf
• File Type:
  [PDF - 219.15 KB ]