Cytochrome C/Cardiolipin Relations in Mitochondria: A Kiss of Death

Details

• Personal Author:
  Bayir HA ; Belikova NA ; Borisenko G ; Greenberger JS ; Jiang JF ; Kagan VE ; Kapralov O ; Kochanek PM ; Pitt B ; Shvedova AA ; Stoyanovsky DA ; Tyurin VA ; Tyurina YY ; Wipf P
• Description:
  Recently, phospholipid peroxidation products gained a reputation as key regulatory molecules and participants in oxidative signaling pathways. During apoptosis, a mitochondria-specific phospholipid, cardiolipin (CL), interacts with cytochrome c (cyt c) to form a peroxidase complex that catalyzes CL oxidation; this process plays a pivotal role in the mitochondrial stage of the execution of the cell death program. This review is focused on redox mechanisms and essential structural features of cyt c's conversion into a CL-specific peroxidase that represent an interesting and maybe still unique example of a functionally significant ligand change in hemoproteins. Furthermore, specific characteristics of CL in mitochondria-its asymmetric transmembrane distribution and mechanisms of collapse, the regulation of its synthesis, remodeling, and fatty acid composition-are given significant consideration. Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented. [Description provided by NIOSH]
• Subjects:
  Free Radicals Occupational Health Oxidants Safety
• Keywords:
  Apoptosis Author Keywords: Cytochrome C Autophagy Cardiolipin Cell-biology Cell-growth Cell-metabolism Cell-morphology Cellular-reactions Free Radicals Humans Lipidomics Mitochondrial Targeting Oxidative-metabolism Oxidative-processes Oxidative Stress Peroxidase

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• ISSN:
  0891-5849
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  46
• Issue:
  11
• NIOSHTIC Number:
  nn:20035427
• Citation:
  Free Radic Biol Med 2009 Jun; 46(11):1439-1453
• Contact Point Address:
  VE Kagan, Ctr Free Rad & Antioxidant Hlth, Pittsburgh, PA 15219
• Email:
  kagan@pitt.edu
• Federal Fiscal Year:
  2009
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Free Radical Biology and Medicine
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b1cfb9cec1e584e5ef1a9179af3298092223e73c11bd7e7510d3300880896d8b6ce0b7bd200f3fdffc96186e693790ce61f2b4a76cb1267dc06c74270b65dbbc
• Download URL:
  https://stacks.cdc.gov/view/cdc/187288/cdc_187288_DS1.pdf
• File Type:
  [PDF - 1.58 MB ]