Overexpression of the erbB-2 Proto-Oncogene in Canine Osteosarcoma Cell Lines and Tumors

Details

• Personal Author:
  Dernell W ; Flint AF ; Hanneman WH ; Legare ME ; U'Ren L ; Withrow SJ
• Description:
  The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. In this study we used real-time reverse transcriptase polymerase chain reaction to evaluate erbB-2 expression in seven canine OSA cell lines and 10 canine OSA tissue samples. We determined erbB-2 to be significantly overexpressed in 86% (six of seven) of the cell lines and 40% (4 of 10) of the OSA tissues samples. Given the importance of erbB-2 in human breast cancer, the finding of erbB-2 overexpression in canine OSA may be important in further understanding the pathogenesis and possible therapies of OSA. [Description provided by NIOSH]
• Subjects:
  Animals Chemistry Growth Musculoskeletal Diseases Musculoskeletal System Neoplasms Occupational Health Safety
• Keywords:
  Animal-studies Author Keywords: Canine Model Bone-cancer Bone-disorders Bone-structure Cancer Cancer-rates Chemical-reactions Chemical-synthesis Dogs ErbB-2 Exposure-levels Exposure-limits Exposure-methods Growth-disorders Growth-factors Growth-inhibition Growth-inhibitors HER2 Oncogenesis Oncogenic-agents Oncogenicity Osteosarcoma Pathogenesis Pathogenicity Pathogens

  More +
• ISSN:
  0300-9858
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  291-296
• Volume:
  41
• Issue:
  3
• NIOSHTIC Number:
  nn:20035332
• Citation:
  Vet Pathol 2004 May; 41(3):291-296
• Contact Point Address:
  A. F. Flint, Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Campus Delivery, Building Physiology 1680, Fort Collins, CO 80523
• Email:
  hanneman@colostate.edu
• Federal Fiscal Year:
  2004
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Veterinary Pathology
• End Date:
  20030929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a541759b7e7edcf8aeb02e4b14b977ab57ae34863e20043e5fba1d02275e5b1a920caaa3e51f9cf7f4f9af149c2ddbfd777bdfe913041bd53d9c09d3d76bd872
• Download URL:
  https://stacks.cdc.gov/view/cdc/187234/cdc_187234_DS1.pdf
• File Type:
  [PDF - 675.68 KB ]