Absorption, Distribution, and Excretion of [14C]-3-Chloro-4-Methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Details

• Personal Author:
  Goldade DA ; Johnston JJ ; Tessari D
• Description:
  Ring-labeled [14C]-3-chloro-4-methylaniline hydrochloride (250 microg per bird) was delivered to 21 red-winged blackbirds (Agelaius phoeniceus) and 21 dark-eyed juncos (Junco hyemalis) via oral gavage, and the distribution and excretion of radioactivity were determined at 15 and 30 min and 1, 4, 8, 12, and 24 h (n = 3 per time point). Direct measurement of radioactivity as well as measurement following combustion was accomplished using a liquid scintillation counter. Elimination from most tissues followed a two-compartment model, with very rapid elimination occurring between time 0 and 4 h and a much slower elimination phase occurring after that. The average half-life of elimination for the initial phase in most tissues examined was 0.16 h for juncos and 0.62 h for blackbirds. The average for the slower second phase of elimination was 3.4 h for juncos and 5.4 h for blackbirds. The radioactivity in blackbird kidney tissues did not change significantly for the duration of the test, pointing toward the kidney as a possible site of action for this important agricultural chemical. [Description provided by NIOSH]
• Subjects:
  Agriculture Animals Chemistry Hazardous Substances Hypersensitivity Occupational Health Risk Assessment Risk Factors Safety Safety Management
• Keywords:
  Agricultural-chemicals Agricultural-workers Animal-studies Author Keywords: 3-Chloro-4-methylaniline Hydrochloride Avicide Chemical-analysis Chemical-binding Chemical-composition Chemical-extraction Chemical-hypersensitivity Chemical-indicators Chemical-structure Chemical-synthesis CPTH Dark-eyed Juncos Disposition Exposure-levels Exposure-limits Health-hazards Health-protection Health-standards Red-winged Blackbirds Risk-analysis Risk-factors Safety-education Safety-measures Safety-monitoring Safety-personnel Safety-practices Safety-programs

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• ISSN:
  0021-8561
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  52
• Issue:
  26
• NIOSHTIC Number:
  nn:20035281
• Citation:
  J Agric Food Chem. 2004 Dec; 52(26):8074-8080
• Email:
  David.A.Goldade@usda.gov
• Federal Fiscal Year:
  2005
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Agricultural and Food Chemistry
• End Date:
  20030929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ab5025230199418de1a5a7e7e59f8a8b1fc22c943c47c96ddb5e7b3020e8fee9cadacf944945b5f5393aa0d0c8353e8c8ed07e20b201a6ec187ceb402de06fe5
• Download URL:
  https://stacks.cdc.gov/view/cdc/187192/cdc_187192_DS1.pdf
• File Type:
  [PDF - 253.41 KB ]