Smoking Modifies the Relationship Between XRCC1 Haplotypes and HPV16-Negative Head and Neck Squamous Cell Carcinoma

Details

• Personal Author:
  Applebaum KM ; Christensen BC ; Kelsey KT ; Marsit CJ ; McClean MD ; Nelson HH ; Applebaum KM ; Christensen BC ; Kelsey KT ; Marsit CJ ; McClean MD ; Nelson HH
• Description:
  Reports on the relationship between head and neck squamous cell carcinoma (HNSCC) and polymorphisms in X-ray cross complementing group 1 (XRCC1) have been inconsistent. We hypothesized this may be due to not accounting for Human papillomavirus type-16 (HPV16) and thus examined whether smoking modified the association between XRCC1 haplotypes and HNSCC risk within HPV16 serologic strata. Cases were diagnosed in Greater Boston, Massachusetts. Controls were matched to cases on age, gender and residential town. Genotyping was conducted on three XRCC1 polymorphisms (Arg194Trp, Arg280His and Arg399Gln) and serology was used to determine HPV16 exposure. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, sex, race, education, smoking, alcohol consumption and HPV16 serology. There was no overall association between XRCC1 polymorphisms and HNSCC risk. Smoking did not modify the association between XRCC1 polymorphisms and HNSCC risk among the HPV16 seropositive (p(interaction) = 0.89) but it did for the HPV16 seronegative (p(interaction)=0.04). Among the HPV16 seronegative, heavy smokers with a haplotype containing a variant allele had an increased HNSCC risk (haplotype with 399Gln: OR, 1.35; 95% CI, 0.97-1.86), whereas never/light smokers with variant alleles may have a reduced risk. In sum, the association between XRCC1 and HNSCC risk differed by HPV16 status and smoking. Among the HPV16 seronegative, heavy smokers with XRCC1 variant alleles had an increased HNSCC risk. There was no relationship between XRCC1 and HPV16-related HNSCC, regardless of smoking. Our findings underscore the importance of accounting for HPV16 exposure even when studying susceptibility to HNSCC. [Description provided by NIOSH]
• Subjects:
  Age Factors Disease Vectors Genetics Occupational Health Safety Tobacco Products
• Keywords:
  Age-factors Author Keywords: Human Papillomavirus (HPV) Disease-incidence Disease-vectors DNA Repair Exposure-methods Genes Genetic-factors Head And Neck Squamous Cell Carcinoma (HNSCC) Tobacco XRCC1

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• ISSN:
  0020-7136
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1 ; Rhode Island
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  124
• Issue:
  11
• NIOSHTIC Number:
  nn:20035276
• Citation:
  Int J Cancer 2009 Jun; 124(11):2690-2696
• Contact Point Address:
  Karl T. Kelsey, Center for Environmental Health and Technology, Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI 02912
• Email:
  karl_kelsey@brown.edu
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing ; Manufacturing
• Performing Organization:
  Boston University Medical Campus
• Peer Reviewed:
  True
• Start Date:
  20080801
• Source Full Name:
  International Journal of Cancer
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:58b823fe1f50910892f313c712dbc4dad006ec3d6a22bb13716d1af2fdef7cde902055ac7321ce9b98d3614a20b1c31c3294ea1493fd3fb33968b5749c1cb7b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/187189/cdc_187189_DS1.pdf
• File Type:
  [PDF - 271.10 KB ]