Comparison of Glove Contact Allergen Content and Clinical Patch Test

Details

• Personal Author:
  Beezhold, Donald H. ; Bledsoe TA ; Fowler FJ ; Law, Brandon F. ; Pratt M ; Sasseville D ; Siegel, Paul D. ; Storrs FJ ; Beezhold, Donald H. ; Bledsoe TA ; Fowler FJ ; Law, Brandon F. ; Pratt M ; Sasseville D ; Siegel, Paul D. ; Storrs FJ
• Description:
  Irritant dermatitis, allergic contact dermatitis (ACD) and urticarial reactions have been associated with chemical rubber accelerators present in latex and nitrile/synthetic rubber gloves. In this study, patients reporting to a dermatology clinic with glove associated ACD were allergy patch tested with the North American Contact Dermatitis Group standard rubber allergen series, medical history taken and asked to identify and supply "problem gloves" which they associated with their ACD and if possible "non-problem gloves'. Medical exam, surgical and industrial-type rubber and nitrile gloves from patients were assessed for chemical content including: zinc dithiocarbamates, thiurams, mercaptobenzothiazole (MBT) and its disulfide, dimorpholine, diphenylguanidine, thiourea, and phenylene diamine. Only zinc di-ethyl - (ZDEC) and zinc dibutyl dithiocarbamate (ZDBC), MBT and dimorpholine were found in glove extracts. Considerable discordance was found between clinical patch test results and glove chemical content. Approximately 37% of patients had no discordance. However, similar percents of patients identified "problem gloves" that did not contain their patch test positive allergen or provided "nonproblem gloves" containing the patch test positive allergen. The lowest glove allergen levels associated with a patch test-confirmed ACD were 584, 283 and 590 mu g/g glove of ZDEC, ZDBC and MBT, respectively. Discordance between the allergy patch test and glove chemical accelerator content may be in part attributed to both false positive/negative allergy patch test rates and misidentification of problem/ non-problem gloves due to the delay between glove usage and clinical ACD manifestation. [Description provided by NIOSH]
• Subjects:
  Biological Factors Chemistry Hypersensitivity Occupational Health Personal Protective Equipment Safety Skin Skin Diseases
• Keywords:
  Allergens Allergic-dermatitis Biological-effects Biological-factors Chemical-hypersensitivity Chemical-reactions Dermatology Gloves Skin-disorders Skin-exposure Skin-irritants Skin-sensitivity Skin-tests

  More +
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  314-315
• Volume:
  108
• Issue:
  1
• NIOSHTIC Number:
  nn:20035269
• Citation:
  Toxicologist 2009 Mar; 108(1):314-315
• Federal Fiscal Year:
  2009
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 48th Annual Meeting and ToxExpo, March 15-19, 2009, Baltimore, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:23b7b5b6a6ad1eb045a177b1ef974b1446ae5e9177636b16ddfa6aac38356eb110675d80b48b83377debe29aab77997169b2115d21d56e044f848aca65af55c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/187184/cdc_187184_DS1.pdf
• File Type:
  [PDF - 1.59 MB ]