Vascular Function, Inflammation, and Variations in Cardiac Autonomic Responses to Particulate Matter Among Welders

Details

• Personal Author:
  Cavallari JM ; Chen JC ; Christiani, David C. ; Eisen EA ; Fang SC ; Mittleman MA
• Description:
  Patients with health conditions associated with impaired vascular function and inflammation may be more susceptible to the adverse health effects of fine particulate (particulate matter with a mass median aerodynamic diameter of < / = 2.5 mum (PM(2.5))) exposure. In 2006, the authors conducted a panel study to investigate directly whether vascular function and inflammation (assessed by C-reactive protein) modify PM(2.5)-associated reductions in heart rate variability among 23 young male workers (mean age, 40 years) from Massachusetts. Concurrent 24-hour ambulatory electrocardiogram and personal PM(2.5) exposure information was collected over a total of 36 person-days, including either or both welding and nonwelding days. Linear mixed models were used to examine the 5-minute standard deviation of normal-to-normal intervals (SDNN) in relation to the moving PM(2.5) averages in the preceding 1-4 hours. C-reactive protein levels and 3 measures of vascular function (augmentation index, mean arterial pressure, and pulse pressure) were determined at baseline. The authors observed an inverse association between the 1-hour PM(2.5) and 5-minute SDNN. Greater SDNN declines were observed among those with C-reactive protein (P(interaction) < 0.001) and augmentation index (P = 0.06) values at or above the 75th percentile and pulse pressure values below the 75th percentile (P < 0.001). Systemic inflammation and poorer vascular function appear to aggravate particle-related declines in heart rate variability among workers. [Description provided by NIOSH]
• Subjects:
  Biological Factors Blood Cardiovascular Diseases Cardiovascular System Delivery Of Health Care Health Care Facilities Workforce And Services Mental Health Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Welding Workplace

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• Keywords:
  Author Keywords: Augmentation Biodynamics Biological-effects Biological-factors Biological-function Biological-monitoring Biological-systems Blood-vessels C-reactive Protein Cardiovascular-function Cardiovascular-system Cardiovascular-system-disorders Disease Susceptibility Heart-rate Heart Rate Inflammation Medical-care Medical-monitoring Particle-aerodynamics Particulate Matter Particulates Physical-reactions Physiological-effects Physiological-factors Physiological-function Physiological-measurements Physiological-response Psychological-factors Psychological-reactions Psychological-responses Risk-factors Vascular Diseases Veins Welders Welding Welding-industry Work-environment Work-performance Worker-health Workplace-studies

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  169
• Issue:
  7
• NIOSHTIC Number:
  nn:20035202
• Citation:
  Am J Epidemiol 2009 Apr; 169(7):848-856
• Contact Point Address:
  Dr. Shona C. Fang, Harvard School of Public Health, 665 Huntington Avenue, Building 1, Room 1402, Boston, MA 02115
• Email:
  sfang@hsph.harvard.edu
• Federal Fiscal Year:
  2009
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:26e95c277aa4c3539451a8ba788cca954ecb32c41d61d830531cdd9eef5dcea68ecd2903b02b081c5b437bb2fd3086f758c0cf262bb770f2848316822ee3296a
• Download URL:
  https://stacks.cdc.gov/view/cdc/187130/cdc_187130_DS1.pdf
• File Type:
  [PDF - 126.06 KB ]