Age at Natural Menopause and Exposure to Organochlorine Pesticides in Hispanic Women

Details

• Personal Author:
  Akkina JE ; Bachand AM ; Keefe TJ ; Reif JS
• Description:
  A cross-sectional study was conducted to evaluate the relationship between exposure to selected organochlorine pesticides (OCP) (p,p'-DDT, p',p'-DDE, dieldrin, hexachlorobenzene, beta-hexachlorocyclohexane [beta-HCH], oxychlordane, trans' nonachlor) and age at natural menopause in a sample of 219 menopausal women participating in the Hispanic Health and Nutrition Examination Survey in 1982-1984. Information on age at menopause, reproductive history, demographic variables, and potential confounding variables was collected via interview. Analysis of variance was employed to compare adjusted mean age at natural menopause among women by category of serum OCP level. Serum levels of p,p'-DDT, p,p'-DDE, beta-HCH, and trans-nonachlor were associated with a younger age at menopause. In particular, women with exposure levels in the highest exposure categories (serum p,p'-DDT > or = 6ppb, beta-HCH > or = 4ppb, or trans-nonachlor > or = 2ppb) had an adjusted mean age at menopause on average 5.7, 3.4, and 5.2 yr earlier, respectively, than women with serum levels of these pesticides below the detection limit. Women with serum p,p'-DDE levels greater than 23.6 ppb (highest quintile) had an adjusted mean age at menopause 1.7 yr earlier than women with serump,p'-DDE levels less than 5.5 ppb (lowest quintile). However, no consistent dose-response effect was apparent across low, medium, and high exposure categories. Interactions were detected for p,p'-DDT in combination with beta-HCH, trans-nonachlor, or oxychlordane, as well as beta-HCH in combination with oxychlordane. [Description provided by NIOSH]
• Subjects:
  Agriculture Chemistry Chlorine Compounds Education Environmental Monitoring Family Farmers Hazardous Substances Hypersensitivity Insecticides Occupational Exposure Occupational Health Safety Safety Management

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• Keywords:
  Agricultural-chemicals Agricultural-products Agricultural-workers Chemical-analysis Chemical-composition Chemical-hypersensitivity Chemical-properties Chemical-reactions Exposure-assessment Exposure-levels Exposure-limits Families Health-hazards Health-protection Occupational-exposure Occupational-hazards Occupational-health Occupations Organo-chlorine-compounds Pesticide-residues Pesticides Pesticides-and-agricultural-chemicals Safety-climate Safety-education Safety-measures Safety-monitoring Safety-personnel Safety-practices

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• ISSN:
  1528-7394
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  67
• Issue:
  18
• NIOSHTIC Number:
  nn:20035154
• Citation:
  J Toxicol Environ Health A 2004 Sep; 67(18):1407-1422
• Contact Point Address:
  J. E. Akinna, U.S. Department of Agriculture, Animal Plant Health Inspection Service, Veterinary Services, Centers for Epidemiology and Animal Health, Fort Collins, Colorado 80526-8117
• Email:
  judy.e.akkina@usda.gov
• CAS Registry Number:
  Dieldrin (CAS RN 60-57-1)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• End Date:
  20030929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fd180f59050620f827900d18e4b46216dfb9ff93f01f7e0cf848834a9dece4bc0275334b9f7edd22c958eeaf2909dd0c32954f76bf19864cbd4472974a267429
• Download URL:
  https://stacks.cdc.gov/view/cdc/187096/cdc_187096_DS1.pdf
• File Type:
  [PDF - 242.97 KB ]