Inflammation – More than One Explanation – Response

Details

• Personal Author:
  Castranova, Vincent ; Vallyathan V ; Weber K
• Description:
  We appreciate the interest shown by Dr. Ginsburg in our recent conference proceedings (EHP 102, supplement 10). As stated in the preface of those proceedings, The Oxygen Radicals and Lung Injury Conference was the first of its kind dedicated to pulmonary science. Therefore, in this conference, the primary attempt was to focus on oxygen radicals and their involvement in toxic insults and the ensuing pathophysiological processes in the lung. We did not ignore the importance of multifactorial relationships of other cellular reactions and products involved in cellular damage and injury. In fact, these issues were addressed in the presentations of Ward (1), Holian et al. (2), Repine (3), Torphy et al. (4), and Demers and Kuhn (5). The complex network of micromolecular reactions have not been fully defined to understand the coordination, modulation, and integration of cellular functions. In many pulmonary diseases (e.g., cancer, emphysema, pneumoconiosis) in which oxygen radicals are implicated, the disease becomes evident only after several years. Subtle damage or changes to biomolecules and their relationships to the coordination and interactions of oxygen radical generation and degradation are important issues to be dealt with in greater detail to understand the synergistic concepts of lung dieases. We hope that future conferences will address these and other issues. [Description provided by NIOSH]
• Subjects:
  Lung Lung Diseases Occupational Health Oxidants Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Biological-effects Biological-transport Cell-function Cellular-function Cellular-transport-mechanism Lung-disease Lung-disorders Lung-irritants Molecular-biology Oxidation Oxidative-metabolism Physiological-disorders Physiological-effects Physiological-response Physiological-testing Physiology Physiopathology Pulmonary-disorders Pulmonary-system Pulmonary-system-disorders

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• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  103
• Issue:
  11
• NIOSHTIC Number:
  nn:20035132
• Citation:
  Environ Health Perspect 1995 Nov; 103(11):985
• Contact Point Address:
  Val Vallythan, CDC, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505
• Federal Fiscal Year:
  1996
• Peer Reviewed:
  False
• Source Full Name:
  Environmental Health Perspectives
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bf5fe43bccf7793102d6d24203a011867ec8ad7007fe7562f47820732f8158a5445e654b44c3b7e8fbac49a29a56dd107c9f38314017261145c3ffa982525196
• Download URL:
  https://stacks.cdc.gov/view/cdc/187088/cdc_187088_DS1.pdf
• File Type:
  [PDF - 219.90 KB ]