Beyond Apoptosis of JNK1 in Liver Cancer

Details

• Personal Author:
  Castranova, Vincent ; Chen F
• Description:
  Hepatocellular Carcinoma (HCC) is the fourth most common neoplasm and the third leading cause of cancer-related death worldwide. Tremendous effort has been made during the past several years in understanding the molecular mechanisms governing the pathogenesis and progression of HCC. Recent studies indicated that c-Jun N-terminal kinase 1 (JNK1), but not JNK2, played pivotal role in the expression of the key signature genes and the prognostic outcomes of HCC. Accordingly, we believe that targeting JNK1 is not only mechanistically sound but also clinically feasible for the treatment of HCC. [Description provided by NIOSH]
• Subjects:
  Carcinogens Genetics Hazardous Substances Liver Neoplasms Occupational Health Safety
• Keywords:
  Apotosis Author Keywords: JNK1 Biological-monitoring Biological-systems Biological-transport Carcinogenesis Carcinogenicity Carcinomas Cell-biology Cell-damage Cell-function Cell-morphology Cellular-function Cellular-reactions Epigenetics Genes Genetic-factors HCC Hepatocytes Hepatotoxicity Hepatotoxins Liver-cancer Liver-cells Liver-disorders Toxic-effects

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• ISSN:
  1538-4101
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  8
• NIOSHTIC Number:
  nn:20035123
• Citation:
  Cell Cycle 2009 Apr; 8(8):1145-1147
• Contact Point Address:
  Fei Chen, CDC, National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, Health Effects Laboratory Division, Rm. 2015, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  lfd3@cdc.gov
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing ; Mining
• Peer Reviewed:
  True
• Source Full Name:
  Cell Cycle
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7a24f7bf5b55693fc867a7faaf40964f1b8943b27232ea974544058d4dead389b98da2ccf07c7cc1cde444ed5771ba1e01347ec6b209c85e035b59eed969ccf7
• Download URL:
  https://stacks.cdc.gov/view/cdc/187081/cdc_187081_DS1.pdf
• File Type:
  [PDF - 378.14 KB ]