Vibration Exposure Induces Mechanical Hyperalgesia in Lean but Not Fatty Zucker Rats

Details

• Personal Author:
  Johnson C ; Krajnak, Kristine M. ; Miller R ; Waugh, Stacey
• Description:
  Repeated use of powered hand-tools can result in the development of vibration-induced neuropathy in the hands of workers. It has been hy­pothesized that workers with metabolic syndrome or diabetes may be at greater risk of developing a vibration-induced neuropathy. However, these workers are usually excluded from epidemiological studies, so their risk of developing a vibration-induced neuropathy is unknown. The goal of this study was to use a rat-tail model of hand-arm vibration syndrome to characterize changes in sensory nerve function that occur in response to vibration exposure in fatty Zucker rats, an animal model of metabolic syndrome. Rats were exposed to tail vibration or restraint­control conditions 4 h/day for 10 days. A-beta, A-delta, and C-fiber function was assessed using transcutaneous electrical stimulation at 3 different fre­quencies. Average thresholds at each frequency were analyzed using mixed-model ANOVAs. Thresholds were measured before and after vi­bration exposure on days 1, 5 and 10. Previous data from our lab dem­onstrated that repeated exposure to vibration results in a reduction in A-beta and A-delta fiber thresholds and demyelination of tail nerves in Sprague Dawley rats. In this study vibration also resulted in a reduction in A-beta­fiber thresholds in lean (control) but not in fatty Zucker rats, suggesting vibration may have increased sensitivity to mechanical stimuli in lean rats. The increase in A-beta-fiber sensitivity was associated with an increase in circulating calcitonin-gene related peptide (CGRP) concentrations in lean rats. In contrast, circulating CGRP concentrations were reduced by vibration in fatty rats. Vibration did not affect A-delta- or C-fiber thresholds in either group of rats. These findings suggest that metabolic disorder or diabetes may not increase the risk of developing a vibration-induced neuropathy. They also suggest that changes in circulating CGRP levels may serve as an early biomarker for detecting vibration-induced nerve injuries in workers. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Nervous System Occupational Health Safety Vibration
• Keywords:
  Animal-studies Laboratory-animals Neurological-reactions Vibration-disease Vibration-effects Vibration-exposure
• ISSN:
  1526-5900
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• Issue:
  4
• NIOSHTIC Number:
  nn:20034964
• Citation:
  J Pain 2008 Apr; 9(4)(Suppl 2):P6
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Journal of Pain
• Supplement:
  2
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a9a9f3d8ec2a367895d068b5b643ea4d80e1b5debf9114b7e253617c7b4525866715cb9596fcfab71eac66f93b6c15adc92e378312713af05d4fd7a95a1175db
• Download URL:
  https://stacks.cdc.gov/view/cdc/186971/cdc_186971_DS1.pdf
• File Type:
  [PDF - 40.83 KB ]