Adaptive Stretch-Shortening Contractions: Diminished Regenerative Capacity with Aging

Details

• Personal Author:
  Baker BA ; Cutlip, Robert G. ; Hollander MS ; Kashon ML ; Mercer RR
• Description:
  This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in young and old rats, following an acute exposure to adaptive SSCs at 6, 24, 48, 72, and 120 h postexposure (n = 6 for each age at each recovery period). Following SSC exposure, all performance measures were decreased in old rats throughout the 120 h acute phase. Estimates of edema were increased in the old vs. young exposed muscle at 120 h recovery. Both young and old rats displayed an increase in developmental myosin heavy chain (MHCdev+) labeling in the exposed muscle, indicating muscle regeneration. However, old rats displayed diminished MHCdev+ labeling, compared with young rats, suggesting limited remodeling and (or) regenerative capacity. Based on these data, diminished local muscle remodeling and (or) regeneration with aging may limit skeletal muscle adaptation following mechanical loading. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Environmental Monitoring Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Age-factors Author Keywords: Aging Biological-effects Exposure-assessment Exposure-methods Inflammation Laboratory-animals Muscle-contraction Muscle-physiology Muscle-stress Muscle-tension Muscle Regeneration Muscles Musculoskeletal-system Myosin Heavy Chain Physiological-effects Physiological-factors Physiological-measurements Physiological-response Physiological-testing Statistical-analysis Stretch-shortening Contractions

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• ISSN:
  1715-5320
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  33
• Issue:
  6
• NIOSHTIC Number:
  nn:20034922
• Citation:
  Appl Physiol Nutr Metab 2008 Dec; 33(6):1181-1191
• Federal Fiscal Year:
  2009
• Peer Reviewed:
  True
• Source Full Name:
  Applied Physiology, Nutrition, and Metabolism
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:42cded46f431ffc745a675b851eb24a92cf1ea791cdb8f6dfdf04a35acfa4005b31b7a1a5878d3b96a07cfe610751202baabfbc8fc95348b30e59f37b98418e1
• Download URL:
  https://stacks.cdc.gov/view/cdc/186945/cdc_186945_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]